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Testis Specific Serine Kinase 2 (TSSK2)

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DGS-G; FLJ38613; SPOGA2; STK22B; Serine/Threonine Kinase 22B(Spermiogenesis Associated)

Testis Specific Serine Kinase 2 (TSSK2)
CCC D209
HGNC 11401
MGI 1347559
PubMed 19926886
RGD 1304951
UniProt Q96PF2
Wiki TSSK2
Using mouse Tssk2 to search a database, followed by PCR of a testis cDNA library, Hao et al. (2004) cloned human TSSK2. The deduced 358-amino acid protein contains the 12 subdomains characteristic of serine/threonine kinases. TSSK2 and TSSK1 share 72% amino acid identity overall and 83% identity in the kinase region.
Northern blot analysis of human tissues detected a 1.7-kb TSSK2 transcript in testis only. Real-time PCR revealed abundant TSSK2 expression in testis and lower levels in heart, brain, and placenta. Western blot detected TSSK2 at the predicted molecular mass of 40 kD in human sperm and testis. Immunohistochemical analysis localized TSSK2 to the sperm head, with intense staining in the equatorial segment.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Testis Specific Serine Kinase 2 (TSSK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Testis Specific Serine Kinase 2 (TSSK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Testis Specific Serine Kinase 2 (TSSK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Testis Specific Serine Kinase 2 (TSSK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Testis Specific Serine Kinase 2 (TSSK2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Testis Specific Serine Kinase 2 (TSSK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Testis Specific Serine Kinase 2 (TSSK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Testis Specific Serine Kinase 2 (TSSK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Testis Specific Serine Kinase 2 (TSSK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Testis Specific Serine Kinase 2 (TSSK2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Testis Specific Serine Kinase 2 (TSSK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Testis Specific Serine Kinase 2 (TSSK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Testis Specific Serine Kinase 2 (TSSK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Testis Specific Serine Kinase 2 (TSSK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Testis Specific Serine Kinase 2 (TSSK2) ELISA Kit Customized Service Offer
  1. "A transcription map of the DiGeorge and velo-cardio-facial syndrome minimal critical region on 22q11."Hum. Mol. Genet. 5:789-800(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues. A TSSK member is present in the equatorial segment of human sperm."Mol. Hum. Reprod. 10:433-444(2004) [PubMed] [Europe PMC] [Abstract]
  3. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Validation of a testis specific serine/threonine kinase [TSSK] family and the substrate of TSSK1 & 2, TSKS, as contraceptive targets."Soc. Reprod. Fertil. Suppl. 63:87-101(2007) [PubMed] [Europe PMC] [Abstract]
  7. "TSKS concentrates in spermatid centrioles during flagellogenesis."Dev. Biol. 319:201-210(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Targeted deletion of Tssk1 and 2 causes male infertility due to haploinsufficiency."Dev. Biol. 319:211-222(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Expression and localization of five members of the testis-specific serine kinase (Tssk) family in mouse and human sperm and testis."Mol. Hum. Reprod. 17:42-56(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Some single-nucleotide polymorphisms of the TSSK2 gene may be associated with human spermatogenesis impairment."J. Androl. 31:388-392(2010) [PubMed] [Europe PMC] [Abstract]