Ribonuclease A4 (RNASE4)

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RNS4; Rnase-A4; Ribonuclease,RNase A Family 4

Ribonuclease A4 (RNASE4)
Rosenberg and Dyer (1995) referred to the protein as ribonuclease 4 (RNase4). By PCR analysis of human/hamster somatic cell hybrids, they determined that the gene encoding the protein resides in a single exon found on human chromosome 14.By Northern analysis, mRNA for the gene was detected in human pancreas, lung, skeletal muscle, heart, kidney, and placenta, but not brain; liver represented the most abundant source. The authors noted that the mRNA encoding this ribonuclease is approximately 2 kb in length, or approximately twice as long as the mRNAs encoding other members of this gene family. They also detected a larger (approximately 2.4 kb), second transcript in hepatic, pancreatic and renal tissues. At the time of creation of this entry, 1 other protein had the name ribonuclease 4: RNS4, which is located on chromosome 1

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD190Hu01 Recombinant Ribonuclease A4 (RNASE4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD190Hu01 Polyclonal Antibody to Ribonuclease A4 (RNASE4) WB.
LAD190Hu71 Biotin-Linked Polyclonal Antibody to Ribonuclease A4 (RNASE4) WB; IHC; ICC.
Assay Kits SED190Hu ELISA Kit for Ribonuclease A4 (RNASE4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ribonuclease A4 (RNASE4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ribonuclease A4 (RNASE4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ribonuclease A4 (RNASE4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ribonuclease A4 (RNASE4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ribonuclease A4 (RNASE4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ribonuclease A4 (RNASE4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ribonuclease A4 (RNASE4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ribonuclease A4 (RNASE4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ribonuclease A4 (RNASE4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ribonuclease A4 (RNASE4) ELISA Kit Customized Service Offer
  1. "Molecular cloning and expression of human ribonuclease 4 cDNA."Biochim. Biophys. Acta 1261:424-426(1995) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Human ribonuclease 4 (RNase 4): coding sequence, chromosomal localization and identification of two distinct transcripts in human somatic tissues."Nucleic Acids Res. 23:4290-4295(1995) [PubMed] [Europe PMC] [Abstract]
  4. "The amino acid sequence of human ribonuclease 4, a highly conserved ribonuclease that cleaves specifically on the 3' side of uridine."Eur. J. Biochem. 217:401-410(1993) [PubMed] [Europe PMC] [Abstract]
  5. "Isolation and characterization of a human colon carcinoma-secreted enzyme with pancreatic ribonuclease-like activity."Biochemistry 25:7255-7264(1986) [PubMed] [Europe PMC] [Abstract]
  6. "The three-dimensional structure of human RNase 4, unliganded and complexed with d(Up), reveals the basis for its uridine selectivity."J. Mol. Biol. 285:205-214(1999) [PubMed] [Europe PMC] [Abstract]