≡

Mannosyl Oligosaccharide Glucosidase (MOGS)

[Edit]

GCS1; Glucosidase I; Processing A-Glucosidase I

Mannosyl Oligosaccharide Glucosidase (MOGS)
CCC D185
HGNC 24862
MGI 1929872
PubMed 10069805
RGD 69240
UniProt Q13724
Wiki GCS1
Glucosidase I is the first enzyme in the N-linked oligosaccharide processing pathway. GCS1 cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. GCS1 is located in the lumen of the endoplasmic reticulum.GCS1 may also refer to "generative cell specific 1", also called HAP2 (hapless2), a gene of lower eukaryotes which is thought to be responsible for gametes fusion .
De Praeter et al. (2000) identified a glucosidase I defect in a neonate with severe generalized hypotonia and dysmorphic features consistent with congenital disorder of glycosylation type IIb (CDG2B). Molecular studies showed that the patient was a compound heterozygote for 2 missense mutations in the GCS1 gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD185Hu01 Recombinant Mannosyl Oligosaccharide Glucosidase (MOGS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD185Hu01 Polyclonal Antibody to Mannosyl Oligosaccharide Glucosidase (MOGS) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Mannosyl Oligosaccharide Glucosidase (MOGS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mannosyl Oligosaccharide Glucosidase (MOGS) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD185Mu01 Recombinant Mannosyl Oligosaccharide Glucosidase (MOGS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD185Mu01 Polyclonal Antibody to Mannosyl Oligosaccharide Glucosidase (MOGS) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Mannosyl Oligosaccharide Glucosidase (MOGS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mannosyl Oligosaccharide Glucosidase (MOGS) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mannosyl Oligosaccharide Glucosidase (MOGS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mannosyl Oligosaccharide Glucosidase (MOGS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mannosyl Oligosaccharide Glucosidase (MOGS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mannosyl Oligosaccharide Glucosidase (MOGS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mannosyl Oligosaccharide Glucosidase (MOGS) ELISA Kit Customized Service Offer
  1. "Cloning and expression of glucosidase I from human hippocampus."Eur. J. Biochem. 231:344-351(1995) [PubMed] [Europe PMC] [Abstract]
  2. ErratumEur. J. Biochem. 249:912-912(1997)
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  8. "A novel disorder caused by defective biosynthesis of N-linked oligosaccharides due to glucosidase I deficiency."Am. J. Hum. Genet. 66:1744-1756(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Processing of N-linked carbohydrate chains in a patient with glucosidase I deficiency (CDG type IIb)."Glycobiology 12:473-483(2002) [PubMed] [Europe PMC] [Abstract]