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5'-3'Exoribonuclease 2 (XRN2)

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Exoribonuclease II; DHM1-like protein; DHP protein

5'-3'Exoribonuclease 2 (XRN2)
CCC D168
HGNC 12836
MGI 894687
PubMed 22483619
RGD 1310218
UniProt Q9H0D6
Wiki XRN2
XRN2 shares similarity with the mouse Dhm1 and the yeast dhp1 genes. The yeast gene is involved in homologous recombination and RNA metabolism, such as RNA synthesis and RNA trafficking. Complementation studies show that Dhm1 has a similar function in mouse as dhp1.Dhm1 is the mouse homolog of S. pombe dhp1+, which is involved in homologous recombination and RNA metabolism. By EST database searching with the sequence of mouse Dhm1 as query, Zhang et al. (1999) identified the human homolog, which they designated XRN2. XRN2 encodes a predicted 950-amino acid protein with 93% identity to Dhm1 and 54% and 42% homology to S. pombe Dhp1+ within putative functional N- and C-terminal regions, respectively.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 5'-3'Exoribonuclease 2 (XRN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 5'-3'Exoribonuclease 2 (XRN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 5'-3'Exoribonuclease 2 (XRN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 5'-3'Exoribonuclease 2 (XRN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for 5'-3'Exoribonuclease 2 (XRN2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 5'-3'Exoribonuclease 2 (XRN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 5'-3'Exoribonuclease 2 (XRN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 5'-3'Exoribonuclease 2 (XRN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 5'-3'Exoribonuclease 2 (XRN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for 5'-3'Exoribonuclease 2 (XRN2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 5'-3'Exoribonuclease 2 (XRN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 5'-3'Exoribonuclease 2 (XRN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 5'-3'Exoribonuclease 2 (XRN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 5'-3'Exoribonuclease 2 (XRN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for 5'-3'Exoribonuclease 2 (XRN2) ELISA Kit Customized Service Offer
  1. "Cloning and mapping of the XRN2 gene to human chromosome 20p11.1-p11.2."Genomics 59:252-254(1999) [PubMed] [Europe PMC] [Abstract]
  2. "A novel splice variant of human XRN2 gene is mainly expressed in blood leukocyte."DNA Seq. 16:143-146(2005) [PubMed] [Europe PMC] [Abstract]
  3. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Functional proteomic analysis of human nucleolus."Mol. Biol. Cell 13:4100-4109(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Human 5' -> 3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites."Nature 432:522-525(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Pause sites promote transcriptional termination of mammalian RNA polymerase II."Mol. Cell. Biol. 26:3986-3996(2006) [PubMed] [Europe PMC] [Abstract]
  11. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  14. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  21. "Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination."Mol. Cell 42:794-805(2011) [PubMed] [Europe PMC] [Abstract]
  22. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  23. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]