S100 Calcium Binding Protein A14 (S100A14)

S100A14 is a member of a subfamily of proteins related by Ca(2+)-binding motifs to the EF-hand Ca(2+)-binding protein superfamily.Using a proteomics approach to identify genes upregulated in breast cancer, followed by database analysis and PCR of a breast carcinoma cell line, Adam et al. (2003) cloned S100A14, which they called BCMP84. BCMP84 expression in normal tissue was restricted to stratified squamous epithelium of skin, cervix, and tonsil. Weak staining was seen in normal breast ductal tissue, but strong immunoreactivity was detected in 10 of 58 (17%) breast cancer tissues. BCMP84 was expressed in the plasma membrane of transiently transfected breast carcinoma cells.By fluorescence in situ hybridization, Pietas et al. (2002) mapped the S100A14 gene to chromosome 1q21 in a cluster with at least 15 other S100 genes.