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Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)

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CHR-NA3; CHRN-A3; N-AChRA3; NAChRA3; N-AChR-A3; Neuronal Acetylcholine Receptor Alpha 3

Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)
CCC D143
HGNC 1957
MGI 87887
PubMed 20234319
RGD 2345
UniProt P32297
Wiki CHRNA3
Neuronal acetylcholine receptor subunit alpha-3 is a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues.
The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD143Hu01 Recombinant Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD143Hu01 Polyclonal Antibody to Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3) WB; IHC; ICC; IP.
MAD143Hu21 Monoclonal Antibody to Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3) WB; IHC; ICC; IP.
Assay Kits SED143Hu ELISA Kit for Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3) ELISA Kit Customized Service Offer
  1. "Molecular cloning of human neuronal nicotinic receptor alpha 3-subunit."Neurosci. Lett. 111:351-356(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Expression of mRNAs in human thymus coding for the alpha 3 subunit of a neuronal acetylcholine receptor."Exp. Neurol. 111:175-180(1991) [PubMed] [Europe PMC] [Abstract]
  3. "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits."J. Mol. Neurosci. 7:217-228(1996) [PubMed] [Europe PMC] [Abstract]
  4. "Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32."FEBS Lett. 400:309-314(1997) [PubMed] [Europe PMC] [Abstract]
  5. "The structures of the human neuronal nicotinic acetylcholine receptor beta2- and alpha3-subunit genes (CHRNB2 and CHRNA3)."Hum. Genet. 103:645-653(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Characterization of the human beta4 nAChR gene and polymorphisms in CHRNA3 and CHRNB4."J. Hum. Genet. 46:362-366(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells."Mol. Pharmacol. 68:1431-1438(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Genomics: when the smoke clears."Nature 452:537-538(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25." Nature 452:633-637(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A variant associated with nicotine dependence, lung cancer and peripheral arterial disease." Nature 452:638-642(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1."Nat. Genet. 40:616-622(2008) [PubMed] [Europe PMC] [Abstract]