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Ubiquitin Conjugating Enzyme E2B (UBE2B)

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UBC2; E2-17kDa; HHR6B; HR6B; RAD6B; RAD6 Homolog; Ubiquitin-conjugating enzyme E2-17 kDa; Ubiquitin-protein ligase B; Ubiquitin carrier protein B

Ubiquitin Conjugating Enzyme E2B (UBE2B)
CCC D107
HGNC 12473
MGI 102944
PubMed 12784252
RGD 708345
UniProt P63146
Wiki UBE2B
Ubiquitin-conjugating enzyme E2 B is a protein encoded by the UBE2B gene.The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s.
This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Conjugating Enzyme E2B (UBE2B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Conjugating Enzyme E2B (UBE2B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Conjugating Enzyme E2B (UBE2B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Conjugating Enzyme E2B (UBE2B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Conjugating Enzyme E2B (UBE2B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Conjugating Enzyme E2B (UBE2B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Conjugating Enzyme E2B (UBE2B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Conjugating Enzyme E2B (UBE2B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Conjugating Enzyme E2B (UBE2B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Conjugating Enzyme E2B (UBE2B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Conjugating Enzyme E2B (UBE2B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Conjugating Enzyme E2B (UBE2B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Conjugating Enzyme E2B (UBE2B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Conjugating Enzyme E2B (UBE2B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Conjugating Enzyme E2B (UBE2B) ELISA Kit Customized Service Offer
  1. "The human ubiquitin carrier protein E2(Mr = 17,000) is homologous to the yeast DNA repair gene RAD6."EMBO J. 9:1431-1435(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Mammalian mRNAs encoding protein closely related to ubiquitin-conjugating enzyme encoded by yeast DNA repair gene RAD6."Biochim. Biophys. Acta 1090:81-85(1991) [PubMed] [Europe PMC] [Abstract]
  3. "Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6."Proc. Natl. Acad. Sci. U.S.A. 88:8865-8869(1991) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The human RAD18 gene product interacts with HHR6A and HHR6B."Nucleic Acids Res. 28:2847-2854(2000) [PubMed] [Europe PMC] [Abstract]
  7. "The human homolog of yeast BRE1 functions as a transcriptional coactivator through direct activator interactions."Mol. Cell 20:759-770(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination."J. Cell Biol. 175:703-708(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen."Proc. Natl. Acad. Sci. U.S.A. 103:18107-18112(2006) [PubMed] [Europe PMC] [Abstract]
  10. "The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines."J. Biol. Chem. 285:8595-8604(2010) [PubMed] [Europe PMC] [Abstract]
  11. "WAC, a functional partner of RNF20/40, regulates histone H2B ubiquitination and gene transcription."Mol. Cell 41:384-397(2011) [PubMed] [Europe PMC] [Abstract]
  12. "The NMR structure of the class I human ubiquitin-conjugating enzyme 2b."J. Biomol. NMR 22:89-92(2002) [PubMed] [Europe PMC] [Abstract]