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Arachidonate-12-Lipoxygenase, 12R Type (ALOX12B)

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LOX12B; 12R-LOX; Lipoxygenase, 12R; Epidermis-type lipoxygenase 12

Arachidonate-12-Lipoxygenase, 12R Type (ALOX12B)
CCC D083
HGNC 430
MGI 1274782
PubMed 17429434
RGD 1305330
UniProt O75342
Wiki ALOX12B
12R-lipoxygenase catalyzes the conversion of arachidonic acid to 12R-hydroxyeicosatetraenoic acid (12R-HETE). The ALOX12B cDNA showed the greatest sequence similarity to the second type of human 15S-lipoxygenase (ALOX15B), and was more distantly related to human 12S-lipoxygenase (ALOX12). The 2 are coexpressed in tissues, and either gene can be the site of mutations causing NCIE, indicating a functional relationship. Nonbullous congenital ichthyosiform erythroderma (NCIE) is a nonsyndromic form of autosomal recessive congenital ichthyosis characterized by hyperkeratosis and a disruption in the epidermal permeability barrier. Identification of mutations in two lipoxygenases (LOXs), ALOX12B (12R-LOX) and ALOXE3 (eLOX3), and further functional studies implicate ALOX12B and ALOXE3 in the etiology of NCIE.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD083Hu01 Recombinant Arachidonate-12-Lipoxygenase, 12R Type (ALOX12B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD083Hu01 Polyclonal Antibody to Arachidonate-12-Lipoxygenase, 12R Type (ALOX12B) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Arachidonate-12-Lipoxygenase, 12R Type (ALOX12B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Arachidonate-12-Lipoxygenase, 12R Type (ALOX12B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD083Mu01 Recombinant Arachidonate-12-Lipoxygenase, 12R Type (ALOX12B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD083Mu01 Polyclonal Antibody to Arachidonate-12-Lipoxygenase, 12R Type (ALOX12B) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Arachidonate-12-Lipoxygenase, 12R Type (ALOX12B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Arachidonate-12-Lipoxygenase, 12R Type (ALOX12B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Arachidonate-12-Lipoxygenase, 12R Type (ALOX12B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Arachidonate-12-Lipoxygenase, 12R Type (ALOX12B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Arachidonate-12-Lipoxygenase, 12R Type (ALOX12B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Arachidonate-12-Lipoxygenase, 12R Type (ALOX12B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Arachidonate-12-Lipoxygenase, 12R Type (ALOX12B) ELISA Kit Customized Service Offer
  1. "A 12R-lipoxygenase in human skin: mechanistic evidence, molecular cloning, and expression."Proc. Natl. Acad. Sci. U.S.A. 95:6744-6749(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Human 12(R)-lipoxygenase and the mouse ortholog. Molecular cloning, expression, and gene chromosomal assignment."J. Biol. Chem. 273:33540-33547(1998) [PubMed] [Europe PMC] [Abstract]
  3. "A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1: cloning, physical mapping, and expression."Genomics 73:323-330(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Lipoxygenases mediate the effect of essential fatty acid in skin barrier formation: a proposed role in releasing omega-hydroxyceramide for construction of the corneocyte lipid envelope."J. Biol. Chem. 286:24046-24056(2011) [PubMed] [Europe PMC] [Abstract]
  6. "A role for 12R-lipoxygenase in MUC5AC expression by respiratory epithelial cells."Eur. Respir. J. 40:714-723(2012) [PubMed] [Europe PMC] [Abstract]
  7. "Lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17p13.1."Hum. Mol. Genet. 11:107-113(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3."Biochim. Biophys. Acta 1686:238-247(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Mutation spectrum and functional analysis of epidermis-type lipoxygenases in patients with autosomal recessive congenital ichthyosis."Hum. Mutat. 26:351-361(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Molecular analysis of 250 patients with autosomal recessive congenital ichthyosis: evidence for mutation hotspots in ALOXE3 and allelic heterogeneity in ALOX12B."J. Invest. Dermatol. 129:1421-1428(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Genotypic and clinical spectrum of self-improving collodion ichthyosis: ALOX12B, ALOXE3, and TGM1 mutations in Scandinavian patients."J. Invest. Dermatol. 130:438-443(2010) [PubMed] [Europe PMC] [Abstract]