Carbonic Anhydrase VI (CA6)

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CA-VI; CAVI; GUSTIN; Carbonate dehydratase VI; Salivary carbonic anhydrase; Secreted carbonic anhydrase

Carbonic Anhydrase VI (CA6)
Carbonic anhydrase 6 is one of several isozymes of carbonic anhydrase. This protein is found only in salivary glands and saliva and protein may play a role in the reversible hydratation of carbon dioxide though its function in saliva is unknown.The clones identified a 1.45-kb mRNA that was present in high levels in parotid submandibular salivary glands but absent in other tissues such as sublingual gland, kidney, liver, and prostate. The mature CA VI protein has 291 amino acids, compared to the 259 or 260 residues of the cytoplasmic isozymes; most of the extra amino acids present are in the carboxyl terminal region. The CA VI protein has 35% sequence identity with human CA II, while residues involved in the active site of the enzymes have been conserved. Southern analysis of human DNA indicated that there is only 1 gene coding for CA VI.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD073Hu01 Recombinant Carbonic Anhydrase VI (CA6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD073Hu01 Polyclonal Antibody to Carbonic Anhydrase VI (CA6) WB; IHC; ICC; IP.
MAD073Hu21 Monoclonal Antibody to Carbonic Anhydrase VI (CA6) WB; IHC; ICC; IP.
Assay Kits SED073Hu ELISA Kit for Carbonic Anhydrase VI (CA6) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD073Mu01 Recombinant Carbonic Anhydrase VI (CA6) Positive Control; Immunogen; SDS-PAGE; WB.
RPD073Mu02 Recombinant Carbonic Anhydrase VI (CA6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD073Mu01 Polyclonal Antibody to Carbonic Anhydrase VI (CA6) WB; IHC; ICC; IP.
PAD073Mu02 Polyclonal Antibody to Carbonic Anhydrase VI (CA6) WB; IHC; ICC; IP.
LAD073Mu71 Biotin-Linked Polyclonal Antibody to Carbonic Anhydrase VI (CA6) WB; IHC; ICC.
Assay Kits SED073Mu ELISA Kit for Carbonic Anhydrase VI (CA6) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD073Ra01 Recombinant Carbonic Anhydrase VI (CA6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD073Ra01 Polyclonal Antibody to Carbonic Anhydrase VI (CA6) WB
Assay Kits n/a CLIA Kit for Carbonic Anhydrase VI (CA6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbonic Anhydrase VI (CA6) ELISA Kit Customized Service Offer
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  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
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  5. "A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases."Bioorg. Med. Chem. Lett. 19:1371-1375(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors."J. Am. Chem. Soc. 131:3057-3062(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Crystal structure of human erythrocyte carbonic anhydrase C. VI. The three-dimensional structure at high resolution in relation to other mammalian carbonic anhydrases."Cold Spring Harb. Symp. Quant. Biol. 36:221-231(1972) [PubMed] [Europe PMC] [Abstract]