≡

Adrenocorticotropic Hormone Receptor (ACTHR)

[Edit]

MC2R; MC2-R; Melanocortin 2 Receptor; ACTH Receptor; Adrenocorticotropin receptor; Melanocortin receptor 2

Adrenocorticotropic Hormone Receptor (ACTHR)
CCC D048
HGNC 6930
MGI 96928
PubMed 22357529
RGD 628649
UniProt Q01718
Wiki MC2R
The ACTH receptor is a type of melanocortin receptor (type 2), properly known as MC2, which is specific for ACTH.the ACTHR gene is expressed in normal corporal skin, scalp tissue, compound nevus tissue, basal cell carcinoma tissue, and cultured melanocytes; the CYP11A1 gene is expressed in squamous cell carcinoma tissue, normal facial skin, normal corporal skin, cultured melanocytes, and basal cell carcinoma tissue; the CYP17 gene is expressed in normal facial skin, corporal skin, cultured melanocytes, squamous cell carcinoma cells, and basal cell carcinoma cells; the CYP21A2 gene is expressed in melanoma tissue, squamous cell carcinoma tissue, basal cell carcinoma tissue, normal facial skin, and cultured melanocytes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adrenocorticotropic Hormone Receptor (ACTHR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adrenocorticotropic Hormone Receptor (ACTHR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adrenocorticotropic Hormone Receptor (ACTHR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adrenocorticotropic Hormone Receptor (ACTHR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adrenocorticotropic Hormone Receptor (ACTHR) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adrenocorticotropic Hormone Receptor (ACTHR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adrenocorticotropic Hormone Receptor (ACTHR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adrenocorticotropic Hormone Receptor (ACTHR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adrenocorticotropic Hormone Receptor (ACTHR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adrenocorticotropic Hormone Receptor (ACTHR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD048Ra01 Recombinant Adrenocorticotropic Hormone Receptor (ACTHR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD048Ra01 Polyclonal Antibody to Adrenocorticotropic Hormone Receptor (ACTHR) WB; IHC; ICC; IP.
MAD048Ra21 Monoclonal Antibody to Adrenocorticotropic Hormone Receptor (ACTHR) WB; IHC; ICC; IP.
Assay Kits SED048Ra ELISA Kit for Adrenocorticotropic Hormone Receptor (ACTHR) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The cloning of a family of genes that encode the melanocortin receptors."Science 257:1248-1251(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Molecular cloning of a novel melanocortin receptor."J. Biol. Chem. 268:8246-8250(1993) [PubMed] [Europe PMC] [Abstract]
  5. "Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2."Nat. Genet. 37:166-170(2005) [PubMed] [Europe PMC] [Abstract]
  6. "MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family."Proc. Natl. Acad. Sci. U.S.A. 106:6146-6151(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Regulation of G protein-coupled receptor signaling: specific dominant-negative effects of melanocortin 2 receptor accessory protein 2."Sci. Signal. 3:RA28-RA28(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Molecular insights into inherited ACTH resistance syndromes."Trends Endocrinol. Metab. 5:209-214(1994)
  9. "Familial glucocorticoid deficiency associated with point mutation in the adrenocorticotropin receptor."Lancet 341:461-462(1993) [PubMed] [Europe PMC] [Abstract]
  10. "Hereditary isolated glucocorticoid deficiency is associated with abnormalities of the adrenocorticotropin receptor gene."J. Clin. Invest. 92:2458-2461(1993) [PubMed] [Europe PMC] [Abstract]
  11. "Demonstration by transfection studies that mutations in the adrenocorticotropin receptor gene are one cause of the hereditary syndrome of glucocorticoid deficiency."J. Clin. Endocrinol. Metab. 81:1442-1448(1996) [PubMed] [Europe PMC] [Abstract]
  12. "Novel mutations of the ACTH receptor gene in a female adult patient with adrenal unresponsiveness to ACTH."Clin. Endocrinol. (Oxf.) 53:389-392(2000) [PubMed] [Europe PMC] [Abstract]
  13. "Clinical, genetic, and functional characterization of adrenocorticotropin receptor mutations using a novel receptor assay."J. Clin. Endocrinol. Metab. 87:4318-4323(2002) [PubMed] [Europe PMC] [Abstract]
  14. "Novel human pathological mutations. Gene symbol: MC2R. Disease: Glucocorticoid deficiency."Hum. Genet. 127:112-112(2010) [PubMed] [Europe PMC] [Abstract]