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Opioid Receptor Kappa 1 (OPRk1)

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OPR-K; KOR

Opioid Receptor Kappa 1 (OPRk1)
CCC D043
HGNC 8154
MGI 97439
PubMed 15608558
RGD 69426
UniProt P41145
Wiki OPRK1
The κ-Opioid receptor is a type of opioid receptor which binds the peptide opioid dynorphin as the primary endogenous ligand. κ receptors are widely distributed in the brain (hypothalamus, periaqueductal gray, and claustrum), spinal cord (substantia gelatinosa), and in pain neurons.
Based on receptor binding studies, three variants of the κ-opioid receptor designated κ1, κ2, and κ3 have been characterized. However only one cDNA clone has been identified, hence these receptor subtypes likely arise from interaction of one κ-opioid receptor protein with other membrane associated proteins.κ-Opioid receptor ligands are also known for their characteristic diuretic effects, due to their negative regulation of antidiuretic hormone (ADH).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Opioid Receptor Kappa 1 (OPRk1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Opioid Receptor Kappa 1 (OPRk1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Opioid Receptor Kappa 1 (OPRk1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Opioid Receptor Kappa 1 (OPRk1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Opioid Receptor Kappa 1 (OPRk1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD043Mu01 Recombinant Opioid Receptor Kappa 1 (OPRk1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Opioid Receptor Kappa 1 (OPRk1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Opioid Receptor Kappa 1 (OPRk1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Opioid Receptor Kappa 1 (OPRk1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Opioid Receptor Kappa 1 (OPRk1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Opioid Receptor Kappa 1 (OPRk1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Opioid Receptor Kappa 1 (OPRk1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Opioid Receptor Kappa 1 (OPRk1) Polyclonal Antibody Customized Service Offer
Assay Kits SED043Ra ELISA Kit for Opioid Receptor Kappa 1 (OPRk1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Isolation of a human kappa opioid receptor cDNA from placenta."Biochem. Biophys. Res. Commun. 202:1431-1437(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Kappa-opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system."Proc. Natl. Acad. Sci. U.S.A. 92:7006-7010(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning of a human kappa opioid receptor from the brain."Life Sci. 56:PL201-PL207(1995) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Human kappa opiate receptor second extracellular loop elevates dynorphin's affinity for human mu/kappa chimeras."J. Biol. Chem. 269:25966-25969(1994) [PubMed] [Europe PMC] [Abstract]
  8. "Ezrin-radixin-moesin-binding phosphoprotein-50/Na+/H+ exchanger regulatory factor (EBP50/NHERF) blocks U50,488H-induced down-regulation of the human kappa opioid receptor by enhancing its recycling rate."J. Biol. Chem. 277:27545-27552(2002) [PubMed] [Europe PMC] [Abstract]
  9. "GEC1 interacts with the kappa opioid receptor and enhances expression of the receptor."J. Biol. Chem. 281:7983-7993(2006) [PubMed] [Europe PMC] [Abstract]
  10. "N-glycosylation of the human kappa opioid receptor enhances its stability but slows its trafficking along the biosynthesis pathway."Biochemistry 46:10960-10970(2007) [PubMed] [Europe PMC] [Abstract]
  11. "The role of kappa-opioid receptor activation in mediating antinociception and addiction."Acta Pharmacol. Sin. 31:1065-1070(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Kinase cascades and ligand-directed signaling at the kappa opioid receptor."Psychopharmacology 210:137-147(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Structure of the human kappa-opioid receptor in complex with JDTic."Nature 485:327-332(2012) [PubMed] [Europe PMC] [Abstract]