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Ryanodine Receptor 3 (RYR3)

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HBRR; Brain ryanodine receptor-calcium release channel

Ryanodine Receptor 3 (RYR3)
CCC D032
HGNC 10485
MGI 99684
PubMed 24561552
RGD 68952
UniProt Q15413
Wiki RYR3
Ryanodine receptor 3 is a protein encoded by this gene is both a calcium channel and a receptor for the plant alkaloid ryanodine. RYR3 along with RYR1 control the resting calcium ion concentration in skeletal muscle.
The deduced 4,866-amino acid protein has a calculated molecular mass of about 551 kD. RYR3 contains 4 repeated sequences organized into 2 tandem pairs, as well as 4 highly hydrophobic C-terminal segments. It does not have an N-terminal signal sequence. Northern blot analysis detected a 16-kb transcript expressed at high levels in caudate nucleus, amygdala, and hippocampus, and at lower levels in corpus callosum, substantia nigra, and thalamus. Abundant expression was also detected in skeletal muscle, and a faint signal was detected in heart.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ryanodine Receptor 3 (RYR3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ryanodine Receptor 3 (RYR3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ryanodine Receptor 3 (RYR3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ryanodine Receptor 3 (RYR3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ryanodine Receptor 3 (RYR3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ryanodine Receptor 3 (RYR3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ryanodine Receptor 3 (RYR3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ryanodine Receptor 3 (RYR3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ryanodine Receptor 3 (RYR3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ryanodine Receptor 3 (RYR3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ryanodine Receptor 3 (RYR3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ryanodine Receptor 3 (RYR3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ryanodine Receptor 3 (RYR3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ryanodine Receptor 3 (RYR3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ryanodine Receptor 3 (RYR3) ELISA Kit Customized Service Offer
  1. "Molecular cloning and characterization of a human brain ryanodine receptor."FEBS Lett. 417:157-162(1997) [PubMed] [Europe PMC] [Abstract]
  2. "cDNA cloning and sequencing of the human ryanodine receptor type 3 (RYR3) reveals a novel alternative splice site in the RYR3 gene."FEBS Lett. 423:367-370(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  4. "Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum."Neuroscience 85:205-216(1998) [PubMed] [Europe PMC] [Abstract]
  5. "Involvement of the brain type of ryanodine receptor in T-cell proliferation."FEBS Lett. 352:206-210(1994) [PubMed] [Europe PMC] [Abstract]
  6. "Localization of a novel ryanodine receptor gene (RYR3) to human chromosome 15q14-q15 by in situ hybridization."Genomics 18:163-165(1993) [PubMed] [Europe PMC] [Abstract]
  7. "Isolation and partial cloning of ryanodine-sensitive Ca2+ release channel protein isoforms from human myometrial smooth muscle."FEBS Lett. 372:6-12(1995) [PubMed] [Europe PMC] [Abstract]
  8. "Knock-down of the type 3 ryanodine receptor impairs sustained Ca2+ signaling via the T cell receptor/CD3 complex."J. Biol. Chem. 277:50636-50642(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Characterization of the binding sites for the interactions between FKBP12 and intracellular calcium release channels."Arch. Biochem. Biophys. 517:37-42(2012) [PubMed] [Europe PMC] [Abstract]