Glutathione Peroxidase 4 (GPX4)

[Edit]

MCSP; PHGPx; SnGPx; SnPHGPx; Phospholipid Hydroperoxidase; Phospholipid hydroperoxide glutathione peroxidase, mitochondrial

Glutathione Peroxidase 4 (GPX4)
The antioxidant enzyme GPx4) belongs to the family of glutathione peroxidases, which consists of 8 known mammalian isoenzymes (GPx1-8). Gpx4 catalyzes the reduction of hydrogen peroxide, organic hydroperoxides, and lipid peroxides at the expense of reduced glutathione and functions in the protection of cells against oxidative stress. The oxidized form of glutathione (glutathione disulfide), which is generated during the reduction of hydroperoxides by GPx4, is recycled by glutathione reductase and NADPH/H+. GPx4 differs from the other GPx family members in terms of its monomeric structure, a less restricted dependence on glutathione as reducing substrate, and the ability to reduce lipid-hydroperoxides inside biological membranes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC994Hu01 Recombinant Glutathione Peroxidase 4 (GPX4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC994Hu01 Polyclonal Antibody to Glutathione Peroxidase 4 (GPX4) WB; IHC
MAC994Hu21 Monoclonal Antibody to Glutathione Peroxidase 4 (GPX4) WB; IHC; ICC; IP.
Assay Kits SEC994Hu ELISA Kit for Glutathione Peroxidase 4 (GPX4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC994Mu01 Recombinant Glutathione Peroxidase 4 (GPX4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC994Mu01 Polyclonal Antibody to Glutathione Peroxidase 4 (GPX4) WB; IHC; ICC; IP.
Assay Kits SEC994Mu ELISA Kit for Glutathione Peroxidase 4 (GPX4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glutathione Peroxidase 4 (GPX4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glutathione Peroxidase 4 (GPX4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glutathione Peroxidase 4 (GPX4) Polyclonal Antibody Customized Service Offer
Assay Kits SEC994Ra ELISA Kit for Glutathione Peroxidase 4 (GPX4) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Structure, gene expression, and evolution of primate glutathione peroxidases."Comp. Biochem. Physiol. 141B:428-436(2005) [PubMed] [Europe PMC] [Abstract]