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Tankyrase 2 (TNKS2)

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PARP5B; PARP5C; TANK2; TNKL; Tankyrase-like protein; ADP-ribosyltransferase diphtheria toxin-like 6; TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2

Tankyrase 2 (TNKS2)
CCC C987
HGNC 15677
MGI 1921743
PubMed 22449978
RGD 1305026
UniProt Q9H2K2
Wiki TNKS2
The poly(ADP-ribose) polymerase (PARP) tankyrase-1 contains an ankyrin-repeat domain that binds to various partners, including the telomeric protein TRF1 (telomere-repeat-binding factor 1) and the vesicular protein IRAP (insulin-responsive aminopeptidase). TRF1 binding recruits tankyrase-1 to telomeres and allows its PARP activity to regulate telomere homoeostasis. By contrast, IRAP binding and the Golgi co-localization of tankyrase-1 with IRAP might allow tankyrase-1 to affect the targeting ofIRAP-containing vesicles. A closely related protein, tankyrase-2, has also been implicated in vesicular targeting. Unlike tankyrase-1, tankyrase-2 has not been shown to have PARP activity. In addition, it has not been implicated in telomere homoeostasis, because it did not interact with TRF1 in previous studies.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC987Hu01 Recombinant Tankyrase 2 (TNKS2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC987Hu01 Polyclonal Antibody to Tankyrase 2 (TNKS2) WB,IHC
MAC987Hu22 Monoclonal Antibody to Tankyrase 2 (TNKS2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Tankyrase 2 (TNKS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tankyrase 2 (TNKS2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tankyrase 2 (TNKS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tankyrase 2 (TNKS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tankyrase 2 (TNKS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tankyrase 2 (TNKS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tankyrase 2 (TNKS2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tankyrase 2 (TNKS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tankyrase 2 (TNKS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tankyrase 2 (TNKS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tankyrase 2 (TNKS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tankyrase 2 (TNKS2) ELISA Kit Customized Service Offer
  1. "Novel tankyrase-related gene detected with meningioma-specific sera."Clin. Cancer Res. 7:113-119(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and characterization of TNKL, a member of tankyrase gene family."Genes Immun. 2:52-55(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14."J. Biol. Chem. 276:17172-17180(2001) [PubMed] [Europe PMC] [Abstract]
  4. "TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression."J. Biol. Chem. 276:35891-35899(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase)."Biochem. J. 361:451-459(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres."Mol. Cell. Biol. 22:332-342(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins."Mol. Cell. Proteomics 8:535-546(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling." Nature 461:614-620(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Toward a unified nomenclature for mammalian ADP-ribosyltransferases."Trends Biochem. Sci. 35:208-219(2010) [PubMed] [Europe PMC] [Abstract]
  12. "RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling."Nat. Cell Biol. 13:623-629(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling."PLoS ONE 6:E22595-E22595(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Proteasome regulation by ADP-ribosylation."Cell 153:614-627(2013) [PubMed] [Europe PMC] [Abstract]
  15. "Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains."FEBS J. 278:1086-1097(2011) [PubMed] [Europe PMC] [Abstract]