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Calpain 10 (CAPN10)

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Calcium-activated neutral proteinase 10

Calpain 10 (CAPN10)
CCC C963
HGNC 1477
MGI 1344392
PubMed 15930958
RGD 69354
UniProt Q9HC96
Wiki CAPN10
Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits.
This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. Calpain-10 is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM) and located within the NIDDM1 region. Multiple alternative transcript variants encoding different isoforms have been described for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC963Hu01 Recombinant Calpain 10 (CAPN10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Calpain 10 (CAPN10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calpain 10 (CAPN10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calpain 10 (CAPN10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calpain 10 (CAPN10) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC963Mu01 Recombinant Calpain 10 (CAPN10) Positive Control; Immunogen; SDS-PAGE; WB.
RPC963Mu02 Recombinant Calpain 10 (CAPN10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC963Mu01 Polyclonal Antibody to Calpain 10 (CAPN10) WB; IHC; ICC; IP.
PAC963Mu02 Polyclonal Antibody to Calpain 10 (CAPN10) WB; IHC; ICC; IP.
Assay Kits SEC963Mu ELISA Kit for Calpain 10 (CAPN10) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calpain 10 (CAPN10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calpain 10 (CAPN10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calpain 10 (CAPN10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calpain 10 (CAPN10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calpain 10 (CAPN10) ELISA Kit Customized Service Offer
  1. "Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus." Nat. Genet. 26:163-175(2000) [PubMed] [Europe PMC] [Abstract]
  2. Erratum Nat. Genet. 26:502-502(2000)
  3. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
  8. "A novel 111/121 diplotype in the Calpain-10 gene is associated with type 2 diabetes."J. Hum. Genet. 51:629-633(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Targeted suppression of calpain-10 expression impairs insulin-stimulated glucose uptake in cultured primary human skeletal muscle cells."Mol. Genet. Metab. 91:318-324(2007) [PubMed] [Europe PMC] [Abstract]
  10. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]