Calpain 9 (CAPN9)
[Edit]GC36; nCL4; Novel Calpain Large Subunit-4; Digestive tract-specific calpain; New calpain 4
![Calpain 9 (CAPN9)](/upload/item/img/Calpain-9-(CAPN9)-92962.jpg)
Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress.
Calpain-9 is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPC962Hu01 | Recombinant Calpain 9 (CAPN9) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAC962Hu01 | Polyclonal Antibody to Calpain 9 (CAPN9) | WB,IHC |
Assay Kits | n/a | CLIA Kit for Calpain 9 (CAPN9) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Calpain 9 (CAPN9) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Calpain 9 (CAPN9) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Calpain 9 (CAPN9) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Calpain 9 (CAPN9) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Calpain 9 (CAPN9) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Calpain 9 (CAPN9) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Calpain 9 (CAPN9) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Calpain 9 (CAPN9) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Calpain 9 (CAPN9) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Calpain 9 (CAPN9) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Calpain 9 (CAPN9) | ELISA Kit Customized Service Offer |
- "Molecular cloning and characterization of a novel tissue-specific calpain predominantly expressed in the digestive tract."Biol. Chem. 379:175-183(1998) [PubMed] [Europe PMC] [Abstract]
- "Isolation of two novel genes, down-regulated in gastric cancer."Jpn. J. Cancer Res. 91:459-463(2000) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
- "The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition."J. Mol. Biol. 366:216-229(2007) [PubMed] [Europe PMC] [Abstract]