≡

Crystallin Alpha B (CRYaB)

[Edit]

CRY-AB; CRYA-B; CRYA2; CTPP2; HSPB5; Heat shock protein beta-5; Renal carcinoma antigen NY-REN-27; Rosenthal fiber component

Crystallin Alpha B (CRYaB)
CCC C944
HGNC 2389
MGI 88516
PubMed 22158051
RGD 2414
UniProt P02511
Wiki CRYAB
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens.
These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC944Hu01 Recombinant Crystallin Alpha B (CRYaB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC944Hu01 Polyclonal Antibody to Crystallin Alpha B (CRYaB) WB; IHC; ICC; IP.
MAC944Hu22 Monoclonal Antibody to Crystallin Alpha B (CRYaB) WB; IHC; ICC; IP.
Assay Kits SEC944Hu ELISA Kit for Crystallin Alpha B (CRYaB) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC944Mu01 Recombinant Crystallin Alpha B (CRYaB) Positive Control; Immunogen; SDS-PAGE; WB.
RPC944Mu02 Recombinant Crystallin Alpha B (CRYaB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC944Mu01 Polyclonal Antibody to Crystallin Alpha B (CRYaB) WB; IHC; ICC; IP.
PAC944Mu02 Polyclonal Antibody to Crystallin Alpha B (CRYaB) WB; IHC; ICC; IP.
Assay Kits SEC944Mu ELISA Kit for Crystallin Alpha B (CRYaB) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Crystallin Alpha B (CRYaB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Crystallin Alpha B (CRYaB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Crystallin Alpha B (CRYaB) Polyclonal Antibody Customized Service Offer
Assay Kits SEC944Ra ELISA Kit for Crystallin Alpha B (CRYaB) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The primary structure of the B2 chain of human alpha-crystallin."FEBS Lett. 74:82-84(1977) [PubMed] [Europe PMC] [Abstract]
  2. "Human alpha B-crystallin gene and preferential promoter function in lens."Genomics 7:594-601(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Accumulation of alpha B-crystallin in brains of patients with Alexander's disease is not due to an abnormality of the 5'-flanking and coding sequence of the genomic DNA."Neurosci. Lett. 140:89-92(1992) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Copurification of small heat shock protein with alpha B crystallin from human skeletal muscle."J. Biol. Chem. 267:7718-7725(1992) [PubMed] [Europe PMC] [Abstract]
  7. "Sequence analysis of betaA3, betaB3, and betaA4 crystallins completes the identification of the major proteins in young human lens."J. Biol. Chem. 272:2268-2275(1997) [PubMed] [Europe PMC] [Abstract]
  8. "The major protein expression profile and two-dimensional protein database of human heart."Electrophoresis 16:1160-1169(1995) [PubMed] [Europe PMC] [Abstract]
  9. "Alpha B-crystallin is expressed in non-lenticular tissues and accumulates in Alexander's disease brain."Cell 57:71-78(1989) [PubMed] [Europe PMC] [Abstract]
  10. "Simultaneous racemization and isomerization at specific aspartic acid residues in alpha B-crystallin from the aged human lens."Biochim. Biophys. Acta 1204:157-163(1994) [PubMed] [Europe PMC] [Abstract]
  11. "Post-translational modifications of water-soluble human lens crystallins from young adults."J. Biol. Chem. 269:12494-12502(1994) [PubMed] [Europe PMC] [Abstract]
  12. "Antigens recognized by autologous antibody in patients with renal-cell carcinoma."Int. J. Cancer 83:456-464(1999) [PubMed] [Europe PMC] [Abstract]
  13. "The major in vivo modifications of the human water-insoluble lens crystallins are disulfide bonds, deamidation, methionine oxidation and backbone cleavage."Exp. Eye Res. 71:195-207(2000) [PubMed] [Europe PMC] [Abstract]
  14. "Identification and characterization of a novel protein from Sertoli cells, PASS1, that associates with mammalian small stress protein hsp27."J. Biol. Chem. 275:18724-18731(2000) [PubMed] [Europe PMC] [Abstract]
  15. "Alpha-B crystallin gene (CRYAB) mutation causes dominant congenital posterior polar cataract in humans."Am. J. Hum. Genet. 69:1141-1145(2001) [PubMed] [Europe PMC] [Abstract]
  16. "Ser-59 is the major phosphorylation site in alphaB-crystallin accumulated in the brains of patients with Alexander's disease."J. Neurochem. 76:730-736(2001) [PubMed] [Europe PMC] [Abstract]
  17. "In vivo carbamylation and acetylation of water-soluble human lens alphaB-crystallin lysine 92."Protein Sci. 10:1130-1136(2001) [PubMed] [Europe PMC] [Abstract]
  18. "Myofibrillar myopathy caused by novel dominant negative alpha B-crystallin mutations."Ann. Neurol. 54:804-810(2003) [PubMed] [Europe PMC] [Abstract]
  19. "Association of the chaperone alphaB-crystallin with titin in heart muscle."J. Biol. Chem. 279:7917-7924(2004) [PubMed] [Europe PMC] [Abstract]
  20. "HSPB7 is a SC35 speckle resident small heat shock protein."Biochim. Biophys. Acta 1793:1343-1353(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Importance of eye lens alpha-crystallin heteropolymer with 3:1 alphaA to alphaB ratio: stability, aggregation, and modifications."IUBMB Life 62:693-702(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Infantile muscular dystrophy in Canadian aboriginals is an alphaB-crystallinopathy."Ann. Neurol. 69:866-871(2011) [PubMed] [Europe PMC] [Abstract]
  23. "Acetylation of alphaA-crystallin in the human lens: effects on structure and chaperone function."Biochim. Biophys. Acta 1822:120-129(2012) [PubMed] [Europe PMC] [Abstract]
  24. "Identification of histidine residues involved in Zn(2+) binding to alphaA- and alphaB-Crystallin by chemical modification and MALDI TOF mass spectrometry."Protein J. 31:623-640(2012) [PubMed] [Europe PMC] [Abstract]
  25. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  26. "A missense mutation in the alphaB-crystallin chaperone gene causes a desmin-related myopathy."Nat. Genet. 20:92-95(1998) [PubMed] [Europe PMC] [Abstract]
  27. "Alteration of protein-protein interactions of congenital cataract crystallin mutants."Invest. Ophthalmol. Vis. Sci. 44:1155-1159(2003) [PubMed] [Europe PMC] [Abstract]
  28. "Crystal structures of alpha-crystallin domain dimers of alphaB-crystallin and Hsp20."J. Mol. Biol. 392:1242-1252(2009) [PubMed] [Europe PMC] [Abstract]
  29. "Alpha B-crystallin mutation in dilated cardiomyopathy."Biochem. Biophys. Res. Commun. 342:379-386(2006) [PubMed] [Europe PMC] [Abstract]
  30. "alphaB-crystallin mutation in dilated cardiomyopathies: low prevalence in a consecutive series of 200 unrelated probands."Biochem. Biophys. Res. Commun. 346:1115-1117(2006) [PubMed] [Europe PMC] [Abstract]
  31. "A novel CRYAB mutation resulting in multisystemic disease."Neuromuscul. Disord. 22:66-72(2012) [PubMed] [Europe PMC] [Abstract]