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Neuropeptide S Receptor (NPSR)

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ASRT2; GPR154; GPRA; NPSR1; PGR14; VRR1; G Protein-Coupled Receptor For Asthma Susceptibility; G Protein-Coupled Receptor 154; G-protein coupled receptor PGR14

Neuropeptide S Receptor (NPSR)
CCC C931
HGNC 23631
MGI 2441738
PubMed 20950671
RGD 1564154
UniProt Q6W5P4
Wiki NPSR
The NPSR) is a member of the G-protein coupled receptor superfamily of integral membrane proteins which binds neuropeptide S (NPS). It was formally an orphan receptor, GPR154, until the discovery of neuropeptide S as the endogenous ligand.In the CNS, activation of the NPSR by NPS promotes arousal and anxiolytic-like effects.
In addition, mututations in NPSR have been linked to a susceptibility to asthma. Hence NPSR has also been called GPRA (G protein-coupled receptor for asthma susceptibility). Activation of NPSR in the airway epithelium has a number of effects including upregulation of matrix metalloproteinases which are involved in the pathogenesis of asthma.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC931Hu01 Recombinant Neuropeptide S Receptor (NPSR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC931Hu01 Polyclonal Antibody to Neuropeptide S Receptor (NPSR) WB; IHC; ICC; IP.
MAC931Hu21 Monoclonal Antibody to Neuropeptide S Receptor (NPSR) WB; IHC; ICC; IP.
Assay Kits SEC931Hu ELISA Kit for Neuropeptide S Receptor (NPSR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neuropeptide S Receptor (NPSR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neuropeptide S Receptor (NPSR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neuropeptide S Receptor (NPSR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neuropeptide S Receptor (NPSR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neuropeptide S Receptor (NPSR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neuropeptide S Receptor (NPSR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neuropeptide S Receptor (NPSR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neuropeptide S Receptor (NPSR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neuropeptide S Receptor (NPSR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neuropeptide S Receptor (NPSR) ELISA Kit Customized Service Offer
  1. "Characterization of a common susceptibility locus for asthma-related traits." Science 304:300-304(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of GPRA, a novel G protein-coupled receptor related to asthma."Am. J. Respir. Cell Mol. Biol. 33:262-270(2005) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects."Neuron 43:487-497(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Haplotypes of G protein-coupled receptor 154 are associated with childhood allergy and asthma."Am. J. Respir. Crit. Care Med. 171:1089-1095(2005) [PubMed] [Europe PMC] [Abstract]
  7. "G-protein-coupled receptor polymorphisms are associated with asthma in a large German population."Am. J. Respir. Crit. Care Med. 171:1358-1362(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Structure-function relationships in the neuropeptide S receptor: molecular consequences of the asthma-associated mutation N107I."J. Biol. Chem. 281:24704-24712(2006) [PubMed] [Europe PMC] [Abstract]