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Platelet Derived Growth Factor Receptor Like Protein (PDGFRL)

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PRLTS; PDGF-Receptor Beta-Like Tumor Suppressor

Platelet Derived Growth Factor Receptor Like Protein (PDGFRL)
CCC C922
HGNC 8805
MGI 1916047
PubMed 22926996
RGD 1308028
UniProt Q15198
PDGFRL is a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor.
The 375-amino acid protein predicted from this cDNA has hydrophobic sequence at the NH2 terminus, characteristic of signal peptides. It shows 27% and 25% identity with the extracellular domain of platelet-derived growth factor receptor-beta and FMS-like tyrosine kinase (FLT), respectively.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC922Hu01 Recombinant Platelet Derived Growth Factor Receptor Like Protein (PDGFRL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC922Hu01 Polyclonal Antibody to Platelet Derived Growth Factor Receptor Like Protein (PDGFRL) WB; IHC; ICC; IP.
MAC922Hu22 Monoclonal Antibody to Platelet Derived Growth Factor Receptor Like Protein (PDGFRL) WB; IHC; ICC; IP.
Assay Kits SEC922Hu ELISA Kit for Platelet Derived Growth Factor Receptor Like Protein (PDGFRL) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC922Hu CLIA Kit for Platelet Derived Growth Factor Receptor Like Protein (PDGFRL) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC922Mu01 Recombinant Platelet Derived Growth Factor Receptor Like Protein (PDGFRL) Positive Control; Immunogen; SDS-PAGE; WB.
RPC922Mu02 Recombinant Platelet Derived Growth Factor Receptor Like Protein (PDGFRL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC922Mu01 Polyclonal Antibody to Platelet Derived Growth Factor Receptor Like Protein (PDGFRL) WB; IHC; ICC; IP.
PAC922Mu02 Polyclonal Antibody to Platelet Derived Growth Factor Receptor Like Protein (PDGFRL) WB; IHC; ICC; IP.
Assay Kits SEC922Mu ELISA Kit for Platelet Derived Growth Factor Receptor Like Protein (PDGFRL) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC922Mu CLIA Kit for Platelet Derived Growth Factor Receptor Like Protein (PDGFRL) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Platelet Derived Growth Factor Receptor Like Protein (PDGFRL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Platelet Derived Growth Factor Receptor Like Protein (PDGFRL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Platelet Derived Growth Factor Receptor Like Protein (PDGFRL) Polyclonal Antibody Customized Service Offer
Assay Kits SEC922Ra ELISA Kit for Platelet Derived Growth Factor Receptor Like Protein (PDGFRL) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Isolation of a candidate tumor suppressor gene on chromosome 8p21.3-p22 that is homologous to an extracellular domain of the PDGF receptor beta gene."Oncogene 10:891-895(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling."J. Biol. Chem. 284:34954-34963(2009) [PubMed] [Europe PMC] [Abstract]
  5. "Genetic variant on PDGFRL associated with Behcet disease in Chinese Han populations."Hum. Mutat. 34:74-78(2013) [PubMed] [Europe PMC] [Abstract]