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Platelet Derived Growth Factor Subunit B (PDGFB)

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PDGF-B; PDGF2; SIS; SSV; C-sis; Simian Sarcoma Viral(v-sis)Oncogene Homolog; Platelet Derived Growth Factor Beta Polypeptide; Proto-oncogene c-Sis; Becaplermin

Platelet Derived Growth Factor Subunit B (PDGFB)
CCC C921
HGNC 8800
MGI 97528
PubMed 11420709
RGD 3283
UniProt P01127
Wiki PDGFB
Platelet-derived growth factor subunit B is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two splice variants have been identified for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC921Hu01 Recombinant Platelet Derived Growth Factor Subunit B (PDGFB) Positive Control; Immunogen; SDS-PAGE; WB.
APC921Hu01 Active Platelet Derived Growth Factor Subunit B (PDGFB) Cell culture; Activity Assays.
RPC921Hu02 Recombinant Platelet Derived Growth Factor Subunit B (PDGFB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC921Hu01 Polyclonal Antibody to Platelet Derived Growth Factor Subunit B (PDGFB) WB; IHC
MAC921Hu22 Monoclonal Antibody to Platelet Derived Growth Factor Subunit B (PDGFB) WB; IHC; ICC; IP.
LAC921Hu71 Biotin-Linked Polyclonal Antibody to Platelet Derived Growth Factor Subunit B (PDGFB) WB; IHC; ICC.
LAC921Hu81 FITC-Linked Polyclonal Antibody to Platelet Derived Growth Factor Subunit B (PDGFB) WB; IHC; ICC; IF.
Assay Kits SEC921Hu ELISA Kit for Platelet Derived Growth Factor Subunit B (PDGFB) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC921Hu CLIA Kit for Platelet Derived Growth Factor Subunit B (PDGFB) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Platelet Derived Growth Factor Subunit B (PDGFB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Platelet Derived Growth Factor Subunit B (PDGFB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Platelet Derived Growth Factor Subunit B (PDGFB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Platelet Derived Growth Factor Subunit B (PDGFB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Platelet Derived Growth Factor Subunit B (PDGFB) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC921Ra01 Recombinant Platelet Derived Growth Factor Subunit B (PDGFB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC921Ra01 Polyclonal Antibody to Platelet Derived Growth Factor Subunit B (PDGFB) WB; IHC; ICC; IP.
MAC921Ra21 Monoclonal Antibody to Platelet Derived Growth Factor Subunit B (PDGFB) WB; IHC; ICC; IP.
Assay Kits SEC921Ra ELISA Kit for Platelet Derived Growth Factor Subunit B (PDGFB) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC921Ra CLIA Kit for Platelet Derived Growth Factor Subunit B (PDGFB) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC921Po01 Recombinant Platelet Derived Growth Factor Subunit B (PDGFB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC921Po01 Polyclonal Antibody to Platelet Derived Growth Factor Subunit B (PDGFB) WB; IHC; ICC; IP.
MAC921Po21 Monoclonal Antibody to Platelet Derived Growth Factor Subunit B (PDGFB) WB; IHC; ICC; IP.
Assay Kits SEC921Po ELISA Kit for Platelet Derived Growth Factor Subunit B (PDGFB) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC921Po CLIA Kit for Platelet Derived Growth Factor Subunit B (PDGFB) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Platelet Derived Growth Factor Subunit B (PDGFB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Platelet Derived Growth Factor Subunit B (PDGFB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Platelet Derived Growth Factor Subunit B (PDGFB) Polyclonal Antibody Customized Service Offer
Assay Kits SEC921Bo ELISA Kit for Platelet Derived Growth Factor Subunit B (PDGFB) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Transforming potential of human c-sis nucleotide sequences encoding platelet-derived growth factor."Science 225:636-639(1984) [PubMed] [Europe PMC] [Abstract]
  2. "Cultured human endothelial cells express platelet-derived growth factor B chain: cDNA cloning and structural analysis."Nature 316:748-750(1985) [PubMed] [Europe PMC] [Abstract]
  3. "Nucleotide sequence of transforming human c-sis cDNA clones with homology to platelet-derived growth factor."Nucleic Acids Res. 13:5007-5018(1985) [PubMed] [Europe PMC] [Abstract]
  4. "Oncogenic potential of the human platelet-derived growth factor transcriptional unit."Cold Spring Harb. Symp. Quant. Biol. 51:959-966(1986) [PubMed] [Europe PMC] [Abstract]
  5. "Structure and sequence of the human c-sis/platelet-derived growth factor 2 (SIS/PDGF2) transcriptional unit."Proc. Natl. Acad. Sci. U.S.A. 83:2392-2396(1986) [PubMed] [Europe PMC] [Abstract]
  6. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "A novel human c-sis mRNA species is transcribed from a promoter in c-sis intron 1 and contains the code for an alternative PDGF B-like protein."Nucleic Acids Res. 23:2815-2822(1995) [PubMed] [Europe PMC] [Abstract]
  10. "Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma."Nat. Genet. 15:95-98(1997) [PubMed] [Europe PMC] [Abstract]
  11. "Nucleotide sequence analysis identifies the human c-sis proto-oncogene as a structural gene for platelet-derived growth factor."Cell 37:123-129(1984) [PubMed] [Europe PMC] [Abstract]
  12. "The human osteosarcoma cell line U-2 OS expresses a 3.8 kilobase mRNA which codes for the sequence of the PDGF-B chain."FEBS Lett. 198:344-348(1986) [PubMed] [Europe PMC] [Abstract]
  13. "Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus."Nature 304:35-39(1983) [PubMed] [Europe PMC] [Abstract]
  14. "Human platelet-derived growth factor (PDGF): amino-terminal amino acid sequence."Science 220:963-965(1983) [PubMed] [Europe PMC] [Abstract]
  15. "The c-sis gene encodes a precursor of the B chain of platelet-derived growth factor."EMBO J. 3:921-928(1984) [PubMed] [Europe PMC] [Abstract]
  16. "Two PDGF-B chain residues, arginine 27 and isoleucine 30, mediate receptor binding and activation."EMBO J. 10:4113-4120(1991) [PubMed] [Europe PMC] [Abstract]
  17. "Assignment of interchain disulfide bonds in platelet-derived growth factor (PDGF) and evidence for agonist activity of monomeric PDGF."J. Biol. Chem. 267:11260-11266(1992) [PubMed] [Europe PMC] [Abstract]
  18. "PDGF D, a novel protease-activated growth factor."Nat. Cell Biol. 3:517-521(2001) [PubMed] [Europe PMC] [Abstract]
  19. "Dermatofibrosarcoma protuberans of breast."Cancer Genet. Cytogenet. 142:56-59(2003) [PubMed] [Europe PMC] [Abstract]
  20. "Role of platelet-derived growth factors in physiology and medicine."Genes Dev. 22:1276-1312(2008) [PubMed] [Europe PMC] [Abstract]
  21. "Crystal structure of human platelet-derived growth factor BB."EMBO J. 11:3921-3926(1992) [PubMed] [Europe PMC] [Abstract]
  22. "Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex."Proc. Natl. Acad. Sci. U.S.A. 107:11307-11312(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice." Nat. Genet. 45:1077-1082(2013) [PubMed] [Europe PMC] [Abstract]