Dynactin 2 (DCTN2)

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P50; DCTN50; RBP50; 50 kDa dynein-associated polypeptide; Dynactin complex 50 kDa subunit; p50 dynamitin

Dynactin 2 (DCTN2)
Dynactin 2 (p50), also known as DCTN2, encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis.
This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC897Hu01 Recombinant Dynactin 2 (DCTN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC897Hu01 Polyclonal Antibody to Dynactin 2 (DCTN2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Dynactin 2 (DCTN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dynactin 2 (DCTN2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dynactin 2 (DCTN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dynactin 2 (DCTN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dynactin 2 (DCTN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dynactin 2 (DCTN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dynactin 2 (DCTN2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dynactin 2 (DCTN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dynactin 2 (DCTN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dynactin 2 (DCTN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dynactin 2 (DCTN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dynactin 2 (DCTN2) ELISA Kit Customized Service Offer
  1. "Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis."J. Cell Biol. 132:617-633(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]