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Synovial Apoptosis Inhibitor 1 (SYVN1)

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HRD1; Synoviolin; E3 ubiquitin-protein ligase synoviolin

Synovial Apoptosis Inhibitor 1 (SYVN1)
CCC C887
HGNC 20738
MGI 1921376
PubMed 19116932
RGD 1310488
UniProt Q86TM6
Wiki SYVN1
SYVN1is a protein involved in endoplasmic reticulum (ER)-associated degradation. The protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. This gene and the mitochondrial ribosomal protein L49 gene use in their respective 3' UTRs some of the same genomic sequence. Sequence analysis identified two transcript variants that encode different isoforms.The N-terminal half of the deduced 616-amino acid protein contains 6 transmembrane domains and a RING finger domain, and it shares homology with mouse, invertebrate, and yeast Hrd1.Transfection of HRD1 into an astrocytoma cell line resulted in colocalization with PERK, an ER membrane protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Synovial Apoptosis Inhibitor 1 (SYVN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Synovial Apoptosis Inhibitor 1 (SYVN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Synovial Apoptosis Inhibitor 1 (SYVN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Synovial Apoptosis Inhibitor 1 (SYVN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Synovial Apoptosis Inhibitor 1 (SYVN1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Synovial Apoptosis Inhibitor 1 (SYVN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Synovial Apoptosis Inhibitor 1 (SYVN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Synovial Apoptosis Inhibitor 1 (SYVN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Synovial Apoptosis Inhibitor 1 (SYVN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Synovial Apoptosis Inhibitor 1 (SYVN1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Synovial Apoptosis Inhibitor 1 (SYVN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Synovial Apoptosis Inhibitor 1 (SYVN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Synovial Apoptosis Inhibitor 1 (SYVN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Synovial Apoptosis Inhibitor 1 (SYVN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Synovial Apoptosis Inhibitor 1 (SYVN1) ELISA Kit Customized Service Offer
  1. "Human HRD1 protects against ER stress-induced apoptosis through ER-associated degradation."FEBS Lett. 532:147-152(2002) [PubMed] [Europe PMC] [Abstract]
  2. "A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to the yeast Hrd1."Biochem. Biophys. Res. Commun. 303:91-97(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy."Genes Dev. 17:2436-2449(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum."J. Biol. Chem. 279:3525-3534(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway."J. Mol. Biol. 354:1021-1027(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane."Proc. Natl. Acad. Sci. U.S.A. 102:14132-14138(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane."Proc. Natl. Acad. Sci. U.S.A. 102:14296-14301(2005) [PubMed] [Europe PMC] [Abstract]
  11. "A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin."J. Neurochem. 99:1456-1469(2006) [PubMed] [Europe PMC] [Abstract]
  12. "An amphipathic helix targets serum and glucocorticoid-induced kinase 1 to the endoplasmic reticulum-associated ubiquitin-conjugation machinery."Proc. Natl. Acad. Sci. U.S.A. 103:11178-11183(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'." EMBO J. 26:113-122(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Ubiquitin ligase Hrd1 enhances the degradation and suppresses the toxicity of polyglutamine-expanded huntingtin."Exp. Cell Res. 313:538-550(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Ubxd1 is a novel co-factor of the human p97 ATPase."Int. J. Biochem. Cell Biol. 40:2927-2942(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP."J. Biol. Chem. 283:20914-20924(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  18. "OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD."Nat. Cell Biol. 10:272-282(2008) [PubMed] [Europe PMC] [Abstract]
  19. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  20. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  21. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  22. "STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein."Mol. Cell 47:99-110(2012) [PubMed] [Europe PMC] [Abstract]
  23. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]