![Supervillin (SVIL)](/upload/item/img/Supervillin-(SVIL)-92881.jpg)
Supervillin is a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or sever actin filaments. The gene product is tightly associated with both actin filaments and plasma membranes, suggesting a role as a high-affinity link between the actin cytoskeleton and the membrane. Its function may include recruitment of actin and other cytoskeletal proteins into specialized structures at the plasma membrane and in the nuclei of growing cells. Two transcript variants encoding different isoforms of supervillin have been described.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPC881Hu01 | Recombinant Supervillin (SVIL) | Positive Control; Immunogen; SDS-PAGE; WB. |
RPC881Hu02 | Recombinant Supervillin (SVIL) | Positive Control; Immunogen; SDS-PAGE; WB. | |
RPC881Hu03 | Recombinant Supervillin (SVIL) | Positive Control; Immunogen; SDS-PAGE; WB. | |
Antibodies | PAC881Hu01 | Polyclonal Antibody to Supervillin (SVIL) | WB; IHC; ICC; IP. |
PAC881Hu02 | Polyclonal Antibody to Supervillin (SVIL) | WB; IHC; ICC; IP. | |
LAC881Hu71 | Biotin-Linked Polyclonal Antibody to Supervillin (SVIL) | WB; IHC; ICC. | |
LAC881Hu81 | FITC-Linked Polyclonal Antibody to Supervillin (SVIL) | WB; IHC; ICC; IF. | |
MAC881Hu21 | Monoclonal Antibody to Supervillin (SVIL) | WB; IHC; ICC; IP. | |
Assay Kits | n/a | CLIA Kit for Supervillin (SVIL) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Supervillin (SVIL) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Supervillin (SVIL) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Supervillin (SVIL) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Supervillin (SVIL) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Supervillin (SVIL) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Supervillin (SVIL) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Supervillin (SVIL) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Supervillin (SVIL) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Supervillin (SVIL) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Supervillin (SVIL) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Supervillin (SVIL) | ELISA Kit Customized Service Offer |
- "Cloning, characterization, and chromosomal localization of human supervillin (SVIL)."Genomics 52:342-351(1998) [PubMed] [Europe PMC] [Abstract]
- "Archvillin, a muscle-specific isoform of supervillin, is an early expressed component of the costameric membrane skeleton."J. Cell Sci. 116:2261-2275(2003) [PubMed] [Europe PMC] [Abstract]
- "Supervillin-mediated suppression of p53 protein enhances cell survival."J. Biol. Chem. 288:7918-7929(2013) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
- "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
- "Archvillin anchors in the Z-line of skeletal muscle via the nebulin C-terminus."Biochem. Biophys. Res. Commun. 374:320-324(2008) [PubMed] [Europe PMC] [Abstract]
- "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
- "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
- "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
- "Supervillin reorganizes the actin cytoskeleton and increases invadopodial efficiency."Mol. Biol. Cell 20:948-962(2009) [PubMed] [Europe PMC] [Abstract]
- "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
- "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
- "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
- "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
- "How to arm a supervillin: designing F-actin binding activity into supervillin headpiece."J. Mol. Biol. 393:608-618(2009) [PubMed] [Europe PMC] [Abstract]