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Stromal Interaction Molecule 1 (STIM1)

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GOK

Stromal Interaction Molecule 1 (STIM1)
CCC C875
HGNC 11386
MGI 107476
PubMed 23332920
RGD 1306831
UniProt Q13586
Wiki STIM1
Stromal interaction molecule 1 is a type 1 transmembrane protein of unknown function. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. STIM1 has been shown recently to function as a sensor of ER Ca2+ levels.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC875Hu01 Recombinant Stromal Interaction Molecule 1 (STIM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC875Hu01 Polyclonal Antibody to Stromal Interaction Molecule 1 (STIM1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Stromal Interaction Molecule 1 (STIM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Stromal Interaction Molecule 1 (STIM1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Stromal Interaction Molecule 1 (STIM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Stromal Interaction Molecule 1 (STIM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Stromal Interaction Molecule 1 (STIM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Stromal Interaction Molecule 1 (STIM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Stromal Interaction Molecule 1 (STIM1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Stromal Interaction Molecule 1 (STIM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Stromal Interaction Molecule 1 (STIM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Stromal Interaction Molecule 1 (STIM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Stromal Interaction Molecule 1 (STIM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Stromal Interaction Molecule 1 (STIM1) ELISA Kit Customized Service Offer
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  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "GOK: a gene at 11p15 involved in rhabdomyosarcoma and rhabdoid tumor development."Cancer Res. 57:4493-4497(1997) [PubMed] [Europe PMC] [Abstract]
  6. "STIM1: a novel phosphoprotein located at the cell surface."Biochim. Biophys. Acta 1481:147-155(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins."Biochem. J. 357:673-685(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Stromal interaction molecule 1 (STIM1), a transmembrane protein with growth suppressor activity, contains an extracellular SAM domain modified by N-linked glycosylation."Biochim. Biophys. Acta 1596:131-137(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1."Cell 136:876-890(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1)."Proc. Natl. Acad. Sci. U.S.A. 109:8682-8687(2012) [PubMed] [Europe PMC] [Abstract]
  18. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
  19. "STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx."Curr. Biol. 15:1235-1241(2005) [PubMed] [Europe PMC] [Abstract]
  20. "STIM1, an essential and conserved component of store-operated Ca2+ channel function."J. Cell Biol. 169:435-445(2005) [PubMed] [Europe PMC] [Abstract]
  21. "STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane."Nature 437:902-905(2005) [PubMed] [Europe PMC] [Abstract]
  22. "Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1."J. Biol. Chem. 281:24979-24990(2006) [PubMed] [Europe PMC] [Abstract]
  23. "Orai1 and STIM reconstitute store-operated calcium channel function."J. Biol. Chem. 281:20661-20665(2006) [PubMed] [Europe PMC] [Abstract]
  24. "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
  25. "Amplification of CRAC current by STIM1 and CRACM1 (Orai1)."Nat. Cell Biol. 8:771-773(2006) [PubMed] [Europe PMC] [Abstract]
  26. "STIM1 has a plasma membrane role in the activation of store-operated Ca(2+) channels."Proc. Natl. Acad. Sci. U.S.A. 103:4040-4045(2006) [PubMed] [Europe PMC] [Abstract]
  27. "STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation."FASEB J. 22:752-761(2008) [PubMed] [Europe PMC] [Abstract]
  28. "An EB1-binding motif acts as a microtubule tip localization signal."Cell 138:366-376(2009) [PubMed] [Europe PMC] [Abstract]
  29. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  30. "STIM1 mutation associated with a syndrome of immunodeficiency and autoimmunity."N. Engl. J. Med. 360:1971-1980(2009) [PubMed] [Europe PMC] [Abstract]
  31. "A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells."Nat. Cell Biol. 12:436-446(2010) [PubMed] [Europe PMC] [Abstract]
  32. "POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters."Proc. Natl. Acad. Sci. U.S.A. 108:19234-19239(2011) [PubMed] [Europe PMC] [Abstract]
  33. "SARAF inactivates the store operated calcium entry machinery to prevent excess calcium refilling."Cell 149:425-438(2012) [PubMed] [Europe PMC] [Abstract]
  34. "A dominant STIM1 mutation causes Stormorken syndrome."Hum. Mutat. 35:556-564(2014) [PubMed] [Europe PMC] [Abstract]
  35. "STIM1 and SLC24A4 are critical for enamel maturation."J. Dent. Res. 93:94S-100S(2014) [PubMed] [Europe PMC] [Abstract]
  36. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  37. "Activating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis."Proc. Natl. Acad. Sci. U.S.A. 111:4197-4202(2014) [PubMed] [Europe PMC] [Abstract]
  38. "Structural and mechanistic insights into STIM1-mediated initiation of store-operated calcium entry."Cell 135:110-122(2008) [PubMed] [Europe PMC] [Abstract]
  39. "Structural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1)."Proc. Natl. Acad. Sci. U.S.A. 109:5657-5662(2012) [PubMed] [Europe PMC] [Abstract]
  40. "STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry."Nat. Commun. 4:2963-2963(2013) [PubMed] [Europe PMC] [Abstract]
  41. "The inhibitory helix controls the intramolecular conformational switching of the C-terminus of STIM1."PLoS ONE 8:E74735-E74735(2013) [PubMed] [Europe PMC] [Abstract]
  42. "Antiviral and regulatory T cell immunity in a patient with stromal interaction molecule 1 deficiency."J. Immunol. 188:1523-1533(2012) [PubMed] [Europe PMC] [Abstract]
  43. "Constitutive activation of the calcium sensor STIM1 causes tubular-aggregate myopathy." Am. J. Hum. Genet. 92:271-278(2013) [PubMed] [Europe PMC] [Abstract]