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Smoothelin (SMTN)

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SMSMO

Smoothelin (SMTN)
CCC C856
HGNC 11126
MGI 1354727
PubMed 18936687
RGD 1310216
UniProt P53814
Wiki SMTN
Smoothelin is a structural protein that is found exclusively in contractile smooth muscle cells. It associates with stress fibers and constitutes part of the cytoskeleton. This gene is localized to chromosome 22q12.3, distal to the TUPLE1 locus and outside the DiGeorge syndrome deletion. Alternative splicing of this gene results in three transcript variants.
This gene, termed smoothelin (SMTN), encodes a 371-amino acid polypeptide. Sequence analysis revealed that the protein contains a 56-amino acid domain with significant homology to a sequence that flanks the actin-binding domains of dystrophin, utrophin, beta-spectrin, and alpha-actinin. Cell fractionation studies suggested to the authors that smoothelin is a part of the cytoskeleton.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC856Hu01 Recombinant Smoothelin (SMTN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC856Hu01 Polyclonal Antibody to Smoothelin (SMTN) WB; IHC; ICC; IP.
MAC856Hu22 Monoclonal Antibody to Smoothelin (SMTN) WB; IHC; ICC; IP.
Assay Kits SEC856Hu ELISA Kit for Smoothelin (SMTN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Smoothelin (SMTN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Smoothelin (SMTN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Smoothelin (SMTN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Smoothelin (SMTN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Smoothelin (SMTN) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC856Ra01 Recombinant Smoothelin (SMTN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC856Ra01 Polyclonal Antibody to Smoothelin (SMTN) WB; IHC; ICC; IP.
MAC856Ra21 Monoclonal Antibody to Smoothelin (SMTN) WB; IHC; ICC; IP.
Assay Kits SEC856Ra ELISA Kit for Smoothelin (SMTN) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Smoothelin, a novel cytoskeletal protein specific for smooth muscle cells."J. Cell Biol. 134:401-411(1996) [PubMed] [Europe PMC] [Abstract]
  2. "A novel isoform of the smooth muscle cell differentiation marker smoothelin."J. Mol. Med. 77:294-298(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Identification and characterization of novel smoothelin isoforms in vascular smooth muscle."J. Vasc. Res. 38:120-132(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Expression of the smoothelin gene is mediated by alternative promoters."Cardiovasc. Res. 55:850-863(2002) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  11. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]