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Transcription Elongation Regulator 1 (TCERG1)

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CA150; TAF2S; TATA box-binding protein-associated factor 2S; Co-Activator Of 150 kDa; TATA Box Binding Protein(TBP)-Associated Factor,RNA Polymerase II S 150kD

Transcription Elongation Regulator 1 (TCERG1)
CCC C827
HGNC 15630
MGI 1926421
PubMed 22158966
RGD 1311748
UniProt O14776
Wiki TCERG1
Transcription elongation regulator 1 is a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms.
Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription Elongation Regulator 1 (TCERG1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription Elongation Regulator 1 (TCERG1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription Elongation Regulator 1 (TCERG1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription Elongation Regulator 1 (TCERG1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription Elongation Regulator 1 (TCERG1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription Elongation Regulator 1 (TCERG1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription Elongation Regulator 1 (TCERG1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription Elongation Regulator 1 (TCERG1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription Elongation Regulator 1 (TCERG1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription Elongation Regulator 1 (TCERG1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription Elongation Regulator 1 (TCERG1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription Elongation Regulator 1 (TCERG1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription Elongation Regulator 1 (TCERG1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription Elongation Regulator 1 (TCERG1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription Elongation Regulator 1 (TCERG1) ELISA Kit Customized Service Offer
  1. "CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription."Mol. Cell. Biol. 17:6029-6039(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II."Proc. Natl. Acad. Sci. U.S.A. 97:9015-9020(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1."Mol. Cell. Biol. 21:7617-7628(2001) [PubMed] [Europe PMC] [Abstract]
  5. "The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis."Proc. Natl. Acad. Sci. U.S.A. 98:1811-1816(2001) [PubMed] [Europe PMC] [Abstract]
  6. "FF domains of CA150 bind transcription and splicing factors through multiple weak interactions."Mol. Cell. Biol. 24:9274-9285(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "General structural motifs of amyloid protofilaments."Proc. Natl. Acad. Sci. U.S.A. 103:16248-16253(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Solution structure of WW domain and FF domains in transcription elongation regulator 1."Submitted (APR-2007) to the PDB data bank