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Transient Receptor Potential Cation Channel Subfamily M, Member 1 (TRPM1)

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LTRPC1; MLSN1; Melastatin 1; Long transient receptor potential channel 1

Transient Receptor Potential Cation Channel Subfamily M, Member 1 (TRPM1)
CCC C812
HGNC 7146
MGI 1330305
PubMed 20544736
UniProt Q7Z4N2
Wiki TRPM1
Transient receptor potential cation channel subfamily M member 1 is a protein similar to the transient receptor potential (Trp) calcium channel family members. The expression of this protein is inversely correlated with melanoma aggressiveness, suggesting that it suppresses melanoma metastasis. The expression of the TRPM1 gene is regulated by the Microphthalmia-associated transcription factor. Northern blot analysis of mouse tissues and cell lines revealed that melastatin was expressed as a 2.8-kb mRNA in normal eye and in 4 melanoma cell lines; its expression in each of the 4 cell lines was inversely proportional to metastatic potential. In 45 human melanocytic primary neoplasms examined by in situ hybridization, the loss of melastatin expression correlated with the thickness of the melanomas.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC812Hu01 Recombinant Transient Receptor Potential Cation Channel Subfamily M, Member 1 (TRPM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC812Hu01 Polyclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 1 (TRPM1) WB; IHC; ICC; IP.
MAC812Hu22 Monoclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 1 (TRPM1) WB; IHC; ICC; IP.
Assay Kits SEC812Hu ELISA Kit for Transient Receptor Potential Cation Channel Subfamily M, Member 1 (TRPM1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transient Receptor Potential Cation Channel Subfamily M, Member 1 (TRPM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 1 (TRPM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 1 (TRPM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transient Receptor Potential Cation Channel Subfamily M, Member 1 (TRPM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transient Receptor Potential Cation Channel Subfamily M, Member 1 (TRPM1) ELISA Kit Customized Service Offer
  1. "Chromosomal localization and genomic characterization of the mouse melastatin gene (Mlsn1)."Genomics 54:116-123(1998) [PubMed] [Europe PMC] [Abstract].
  2. "TRPM1 forms ion channels associated with melanin content in melanocytes."Sci. Signal. 2:RA21-RA21(2009) [PubMed] [Europe PMC] [Abstract]
  3. "ProX human full-length cDNA cloning project."Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
  4. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis."Cancer Res. 58:1515-1520(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Expression and up-regulation of alternatively spliced transcripts of melastatin, a melanoma metastasis-related gene, in human melanoma cells."Biochem. Biophys. Res. Commun. 279:53-61(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform."Proc. Natl. Acad. Sci. U.S.A. 98:10692-10697(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Recessive mutations of the gene TRPM1 abrogate ON bipolar cell function and cause complete congenital stationary night blindness in humans."Am. J. Hum. Genet. 85:711-719(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Mutations in TRPM1 are a common cause of complete congenital stationary night blindness."Am. J. Hum. Genet. 85:730-736(2009) [PubMed] [Europe PMC] [Abstract]
  11. "TRPM1 is mutated in patients with autosomal-recessive complete congenital stationary night blindness." Am. J. Hum. Genet. 85:720-729(2009) [PubMed] [Europe PMC] [Abstract]