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Trafficking Protein Particle Complex 2 (TRAPPC2)

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MIP-2A; SEDL; SEDT; TRS20; ZNF547L; Sedlin; Spondyloepiphyseal Dysplasia,Late

Trafficking Protein Particle Complex 2 (TRAPPC2)
CCC C808
HGNC 23068
MGI 1913476
PubMed 21858081
RGD 1306925
UniProt P0DI81
Wiki TRAPPC2
Trafficking protein particle complex subunit 2 is a protein thought to be part of a large multisubunit complex involved in the targeting and fusion of endoplasmic reticulum-to-Golgi transport vesicles with their acceptor compartment. In addition, the encoded protein can bind MBP1 and block its transcriptional repression capability.
Mutations in this gene are a cause of spondyloepiphyseal dysplasia tarda (SEDT). A processed pseudogene of this gene is located on chromosome 19, and other pseuodogenes of it are found on chromosome 8 and the Y chromosome. Two transcript variants encoding the same protein have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC808Hu01 Recombinant Trafficking Protein Particle Complex 2 (TRAPPC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC808Hu01 Polyclonal Antibody to Trafficking Protein Particle Complex 2 (TRAPPC2) WB
Assay Kits n/a CLIA Kit for Trafficking Protein Particle Complex 2 (TRAPPC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Trafficking Protein Particle Complex 2 (TRAPPC2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Trafficking Protein Particle Complex 2 (TRAPPC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Trafficking Protein Particle Complex 2 (TRAPPC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Trafficking Protein Particle Complex 2 (TRAPPC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Trafficking Protein Particle Complex 2 (TRAPPC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Trafficking Protein Particle Complex 2 (TRAPPC2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Trafficking Protein Particle Complex 2 (TRAPPC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Trafficking Protein Particle Complex 2 (TRAPPC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Trafficking Protein Particle Complex 2 (TRAPPC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Trafficking Protein Particle Complex 2 (TRAPPC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Trafficking Protein Particle Complex 2 (TRAPPC2) ELISA Kit Customized Service Offer
  1. "Identification of the gene (SEDL) causing X-linked spondyloepiphyseal dysplasia tarda."Nat. Genet. 22:400-404(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Gene structure and expression study of the SEDL gene for spondyloepiphyseal dysplasia tarda."Genomics 69:242-251(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Functional organization of the yeast proteome by systematic analysis of protein complexes." Nature 415:141-147(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking."Mol. Biol. Cell 22:2083-2093(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Human wild-type SEDL protein functionally complements yeast Trs20p but some naturally occurring SEDL mutants do not."Gene 320:137-144(2003) [PubMed] [Europe PMC] [Abstract]
  10. "TRAPPC2L is a novel, highly conserved TRAPP-interacting protein."Traffic 10:724-736(2009) [PubMed] [Europe PMC] [Abstract]
  11. "SEDLIN forms homodimers: characterisation of SEDLIN mutations and their interactions with transcription factors MBP1, PITX1 and SF1."PLoS ONE 5:E10646-E10646(2010) [PubMed] [Europe PMC] [Abstract]
  12. "The molecular basis of X-linked spondyloepiphyseal dysplasia tarda."Am. J. Hum. Genet. 68:1386-1397(2001) [PubMed] [Europe PMC] [Abstract]
  13. "A missense mutation in the SEDL gene results in delayed onset of X linked spondyloepiphyseal dysplasia in a large pedigree."J. Med. Genet. 38:409-411(2001) [PubMed] [Europe PMC] [Abstract]