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Tropomyosin 1 Alpha (TPM1)

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TMSA; C15orf13; HTM-alpha; TPM1-alpha; TPM1-kappa; Tropomyosin-1; Alpha-tropomyosin

Tropomyosin 1 Alpha (TPM1)
CCC C806
HGNC 12010
MGI 98809
PubMed 1629236
RGD 1581483
UniProt P09493
Wiki TPM1
Tropomyosin alpha-1 chain is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tropomyosin 1 Alpha (TPM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tropomyosin 1 Alpha (TPM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tropomyosin 1 Alpha (TPM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tropomyosin 1 Alpha (TPM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tropomyosin 1 Alpha (TPM1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tropomyosin 1 Alpha (TPM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tropomyosin 1 Alpha (TPM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tropomyosin 1 Alpha (TPM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tropomyosin 1 Alpha (TPM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tropomyosin 1 Alpha (TPM1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tropomyosin 1 Alpha (TPM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tropomyosin 1 Alpha (TPM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tropomyosin 1 Alpha (TPM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tropomyosin 1 Alpha (TPM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tropomyosin 1 Alpha (TPM1) ELISA Kit Customized Service Offer
  1. "Relation of streptococcal M protein with human and rabbit tropomyosin: the complete amino acid sequence of human cardiac alpha tropomyosin, a highly conserved contractile protein."Biochem. Biophys. Res. Commun. 142:813-818(1987) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and characterization of a cDNA encoding transformation-sensitive tropomyosin isoform 3 from tumorigenic human fibroblasts."Mol. Cell. Biol. 8:160-168(1988) [PubMed] [Europe PMC] [Abstract]
  3. "Human hTM alpha gene: expression in muscle and nonmuscle tissue."Mol. Cell. Biol. 8:433-440(1988) [PubMed] [Europe PMC] [Abstract]
  4. "Expression of a novel cardiac-specific tropomyosin isoform in humans."Biochem. Biophys. Res. Commun. 320:1291-1297(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Evolution of tropomyosin functional domains: differential splicing and genomic constraints."J. Mol. Evol. 27:228-235(1988) [PubMed] [Europe PMC] [Abstract]
  10. "Autoimmunity to cytoskeletal protein tropomyosin. A clue to the pathogenetic mechanism for ulcerative colitis."J. Immunol. 150:2487-2493(1993) [PubMed] [Europe PMC] [Abstract]
  11. "Cluster analysis of an extensive human breast cancer cell line protein expression map database."Proteomics 2:212-223(2002) [PubMed] [Europe PMC] [Abstract]
  12. "DAP kinase mediates the phosphorylation of tropomyosin-1 downstream of the ERK pathway, which regulates the formation of stress fibers in response to oxidative stress."J. Cell Sci. 120:3666-3677(2007) [PubMed] [Europe PMC] [Abstract]