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Trinucleotide Repeat Containing Protein 6A (TNRC6A)

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CAGH26; GW1; GW182; TNRC6; CAG repeat protein 26; EMSY interactor protein; GW182 autoantigen; Glycine-tryptophan protein of 182 kDa

Trinucleotide Repeat Containing Protein 6A (TNRC6A)
CCC C801
HGNC 11969
MGI 2385292
PubMed 23150874
RGD 1307268
UniProt Q8NDV7
Wiki TNRC6A
Trinucleotide repeat-containing gene 6A protein is a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC801Hu01 Recombinant Trinucleotide Repeat Containing Protein 6A (TNRC6A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC801Hu01 Polyclonal Antibody to Trinucleotide Repeat Containing Protein 6A (TNRC6A) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Trinucleotide Repeat Containing Protein 6A (TNRC6A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Trinucleotide Repeat Containing Protein 6A (TNRC6A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC801Mu01 Recombinant Trinucleotide Repeat Containing Protein 6A (TNRC6A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC801Mu01 Polyclonal Antibody to Trinucleotide Repeat Containing Protein 6A (TNRC6A) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Trinucleotide Repeat Containing Protein 6A (TNRC6A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Trinucleotide Repeat Containing Protein 6A (TNRC6A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Trinucleotide Repeat Containing Protein 6A (TNRC6A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Trinucleotide Repeat Containing Protein 6A (TNRC6A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Trinucleotide Repeat Containing Protein 6A (TNRC6A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Trinucleotide Repeat Containing Protein 6A (TNRC6A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Trinucleotide Repeat Containing Protein 6A (TNRC6A) ELISA Kit Customized Service Offer
  1. "A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles."Mol. Biol. Cell 13:1338-1351(2002) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "cDNAs with long CAG trinucleotide repeats from human brain."Hum. Genet. 100:114-122(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Clinical and serological associations of autoantibodies to GW bodies and a novel cytoplasmic autoantigen GW182."J. Mol. Med. 81:811-818(2003) [PubMed] [Europe PMC] [Abstract]
  9. "The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies."RNA 9:1171-1173(2003) [PubMed] [Europe PMC] [Abstract]
  10. "GW182 is critical for the stability of GW bodies expressed during the cell cycle and cell proliferation."J. Cell Sci. 117:5567-5578(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies."Nat. Cell Biol. 7:633-636(2005) [PubMed] [Europe PMC] [Abstract]
  12. "A role for the P-body component GW182 in microRNA function."Nat. Cell Biol. 7:1261-1266(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Disruption of GW bodies impairs mammalian RNA interference."Nat. Cell Biol. 7:1267-1274(2005) [PubMed] [Europe PMC] [Abstract]
  14. ErratumNat. Cell Biol. 8:100-100(2006)
  15. "Formation of GW bodies is a consequence of microRNA genesis."EMBO Rep. 7:904-910(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system."Genes Dev. 21:1857-1862(2007) [PubMed] [Europe PMC] [Abstract]
  17. ErratumGenes Dev. 21:2509-2509(2007)
  18. "Small interfering RNA-mediated silencing induces target-dependent assembly of GW/P bodies."Mol. Biol. Cell 18:3375-3387(2007) [PubMed] [Europe PMC] [Abstract]
  19. ErratumMol. Biol. Cell 18:4200-4200(2007)
  20. "Identification of GW182 and its novel isoform TNGW1 as translational repressors in Ago2-mediated silencing."J. Cell Sci. 121:4134-4144(2008) [PubMed] [Europe PMC] [Abstract]
  21. "Prolyl 4-hydroxylation regulates Argonaute 2 stability."Nature 455:421-424(2008) [PubMed] [Europe PMC] [Abstract]
  22. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  23. "Localization of double-stranded small interfering RNA to cytoplasmic processing bodies is Ago2 dependent and results in up-regulation of GW182 and Argonaute-2."Mol. Biol. Cell 20:521-529(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression."RNA 15:781-793(2009) [PubMed] [Europe PMC] [Abstract]
  25. "The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing."RNA 15:804-813(2009) [PubMed] [Europe PMC] [Abstract]
  26. "The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins."RNA 15:1059-1066(2009) [PubMed] [Europe PMC] [Abstract]
  27. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  28. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  29. "GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets."Mol. Cell 44:120-133(2011) [PubMed] [Europe PMC] [Abstract]