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Tenomodulin (TNMD)

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TEM; BRICD4; CHM1-LIKE; CHM1L; Myodulin; Tendin; Chondromodulin-1-like protein

Tenomodulin (TNMD)
CCC C798
HGNC 17757
MGI 1929885
PubMed 15632070
RGD 620938
UniProt Q9H2S6
Wiki Tenomodulin
By searching an EST database for sequences similar to mouse Tem, followed by RACE of a human fetus cDNA library, Shukunami et al. (2001) cloned TEM. The deduced 317-amino acid protein contains an N-terminal transmembrane domain and a putative antiangiogenic domain with 8 cysteines.
TEM shares 96% amino acid identity with mouse Tem, and it shares 65% identity in a 65-amino acid C-terminal stretch with chondromodulin I (CHM1). Northern blot analysis of several mouse tissues detected a 1.4-kb transcript expressed specifically in skeletal muscle. In situ hybridization revealed mouse Tem expression in dense connective tissue, such as epimysium and tendon.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC798Hu01 Recombinant Tenomodulin (TNMD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC798Hu01 Polyclonal Antibody to Tenomodulin (TNMD) WB; IHC; ICC; IP.
MAC798Hu22 Monoclonal Antibody to Tenomodulin (TNMD) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Tenomodulin (TNMD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tenomodulin (TNMD) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tenomodulin (TNMD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tenomodulin (TNMD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tenomodulin (TNMD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tenomodulin (TNMD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tenomodulin (TNMD) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tenomodulin (TNMD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tenomodulin (TNMD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tenomodulin (TNMD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tenomodulin (TNMD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tenomodulin (TNMD) ELISA Kit Customized Service Offer
  1. "Molecular cloning and characterization of ChM1L, a novel membrane molecule similar to chondromodulin-I."Biochem. Biophys. Res. Commun. 280:1101-1106(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning of tenomodulin, a novel chondromodulin-I related gene."Biochem. Biophys. Res. Commun. 280:1323-1327(2001) [PubMed] [Europe PMC] [Abstract]
  3. "A novel gene, tendin, is strongly expressed in tendons and ligaments and shows high homology with chondromodulin-I."Dev. Dyn. 221:72-80(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Tenomodulin is highly expressed in adipose tissue, increased in obesity, and down-regulated during diet-induced weight loss."J. Clin. Endocrinol. Metab. 94:3987-3994(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Tendon-selective genes identified from rat and human musculoskeletal tissues."J. Orthop. Res. 28:289-297(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Differential expression and cellular localization of novel isoforms of the tendon biomarker tenomodulin."J. Appl. Physiol. 113:861-871(2012) [PubMed] [Europe PMC] [Abstract]