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Tumor Necrosis Factor Alpha Induced Protein 3 (TNFaIP3)

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A20; OTUD7C; TNFA1P2; OTU domain-containing protein 7C; Putative DNA-binding protein A20; Zinc finger protein A20

Tumor Necrosis Factor Alpha Induced Protein 3 (TNFaIP3)
CCC C796
HGNC 11896
MGI 1196377
PubMed 19165918
UniProt P21580
Wiki TNFAIP3
Tumor necrosis factor, alpha-induced protein 3 is a zinc finger protein, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. Knockout studies of a similar gene in mice suggested that this gene is critical for limiting inflammation by terminating TNF-induced NF-kappa B responses.
Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteosomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC796Hu01 Recombinant Tumor Necrosis Factor Alpha Induced Protein 3 (TNFaIP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC796Hu01 Polyclonal Antibody to Tumor Necrosis Factor Alpha Induced Protein 3 (TNFaIP3) WB; IHC; ICC; IP.
MAC796Hu21 Monoclonal Antibody to Tumor Necrosis Factor Alpha Induced Protein 3 (TNFaIP3) WB; IHC; ICC; IP.
Assay Kits SEC796Hu ELISA Kit for Tumor Necrosis Factor Alpha Induced Protein 3 (TNFaIP3) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC796Hu CLIA Kit for Tumor Necrosis Factor Alpha Induced Protein 3 (TNFaIP3) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tumor Necrosis Factor Alpha Induced Protein 3 (TNFaIP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tumor Necrosis Factor Alpha Induced Protein 3 (TNFaIP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tumor Necrosis Factor Alpha Induced Protein 3 (TNFaIP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tumor Necrosis Factor Alpha Induced Protein 3 (TNFaIP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tumor Necrosis Factor Alpha Induced Protein 3 (TNFaIP3) ELISA Kit Customized Service Offer
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  8. "Epstein-Barr virus-encoded latent membrane protein 1 activates the JNK pathway through its extreme C-terminus via a mechanism involving TRADD and TRAF2."J. Virol. 73:1023-1035(1999) [PubMed] [Europe PMC] [Abstract]
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  13. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  14. "ABIN-1 binds to NEMO/IKKgamma and co-operates with A20 in inhibiting NF-kappaB."J. Biol. Chem. 281:18482-18488(2006) [PubMed] [Europe PMC] [Abstract]
  15. "T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20."Nat. Immunol. 9:263-271(2008) [PubMed] [Europe PMC] [Abstract]
  16. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  17. "The zinc finger protein A20 targets TRAF2 to the lysosomes for degradation."Biochim. Biophys. Acta 1793:346-353(2009) [PubMed] [Europe PMC] [Abstract]
  18. "The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling."EMBO J. 28:513-522(2009) [PubMed] [Europe PMC] [Abstract]
  19. "A20 negatively regulates T cell receptor signaling to NF-kappaB by cleaving Malt1 ubiquitin chains."J. Immunol. 182:7718-7728(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Cleavage by MALT1 induces cytosolic release of A20."Biochem. Biophys. Res. Commun. 400:543-547(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Direct, noncatalytic mechanism of IKK inhibition by A20."Mol. Cell 44:559-571(2011) [PubMed] [Europe PMC] [Abstract]
  23. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  24. "OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis."Cell 154:169-184(2013) [PubMed] [Europe PMC] [Abstract]
  25. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  26. "Solution structure of the A20-type zinc finger domains from human tumor necrosis factor, alpha-induced protein 3."Submitted (OCT-2007) to the PDB data bank
  27. "Structure of the A20 OTU domain and mechanistic insights into deubiquitination."Biochem. J. 409:77-85(2008) [PubMed] [Europe PMC] [Abstract]
  28. "Molecular basis for the unique deubiquitinating activity of the NF-kappaB inhibitor A20."J. Mol. Biol. 376:526-540(2008) [PubMed] [Europe PMC] [Abstract]
  29. "Ubiquitin binding to A20 ZnF4 is required for modulation of NF-kappaB signaling."Mol. Cell 40:548-557(2010) [PubMed] [Europe PMC] [Abstract]