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Telomeric Repeat Binding Factor 1 (TERF1)

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TRF; PIN2; TRBF1; TRF1; hTRF1-AS; t-TRF1; NIMA-interacting protein 2; TTAGGG repeat-binding factor 1; Telomeric protein Pin2/TRF1

Telomeric Repeat Binding Factor 1 (TERF1)
CCC C788
HGNC 11728
MGI 109634
PubMed 15327984
RGD 1311574
UniProt P54274
Wiki TERF1
Telomeric repeat-binding factor 1 is a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products. The mouse Trf1 mRNA was shown to be ubiquitously expressed as a single 1.9-kb polyadenylated transcript in mouse somatic tissues. High levels of a 2.1-kb transcript were found in testes. In vitro translation of the mouse cDNA resulted in a 56-kD protein that binds to TTAGGG repeat arrays.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC788Hu01 Recombinant Telomeric Repeat Binding Factor 1 (TERF1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC788Hu01 Polyclonal Antibody to Telomeric Repeat Binding Factor 1 (TERF1) WB; IHC; ICC; IP.
LAC788Hu81 FITC-Linked Polyclonal Antibody to Telomeric Repeat Binding Factor 1 (TERF1) WB; IHC; ICC; IF.
LAC788Hu71 Biotin-Linked Polyclonal Antibody to Telomeric Repeat Binding Factor 1 (TERF1) WB; IHC; ICC.
MAC788Hu21 Monoclonal Antibody to Telomeric Repeat Binding Factor 1 (TERF1) WB; IHC; ICC; IP.
Assay Kits SEC788Hu ELISA Kit for Telomeric Repeat Binding Factor 1 (TERF1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Telomeric Repeat Binding Factor 1 (TERF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Telomeric Repeat Binding Factor 1 (TERF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Telomeric Repeat Binding Factor 1 (TERF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Telomeric Repeat Binding Factor 1 (TERF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Telomeric Repeat Binding Factor 1 (TERF1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Telomeric Repeat Binding Factor 1 (TERF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Telomeric Repeat Binding Factor 1 (TERF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Telomeric Repeat Binding Factor 1 (TERF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Telomeric Repeat Binding Factor 1 (TERF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Telomeric Repeat Binding Factor 1 (TERF1) ELISA Kit Customized Service Offer
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  2. "Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2."Nat. Genet. 17:231-235(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization and cell cycle regulation of the related human telomeric proteins Pin2 and TRF1 suggest a role in mitosis."Proc. Natl. Acad. Sci. U.S.A. 94:13618-13623(1997) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
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  7. "Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks."J. Biol. Chem. 276:29282-29291(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle."FEBS Lett. 514:193-198(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres."Mol. Cell. Biol. 22:332-342(2002) [PubMed] [Europe PMC] [Abstract]
  10. "POT1 as a terminal transducer of TRF1 telomere length control."Nature 423:1013-1018(2003) [PubMed] [Europe PMC] [Abstract]
  11. "TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres."J. Biol. Chem. 279:47264-47271(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins."J. Biol. Chem. 279:51338-51342(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Shelterin: the protein complex that shapes and safeguards human telomeres."Genes Dev. 19:2100-2110(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  15. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Ubiquitin ligase RLIM modulates telomere length homeostasis through a proteolysis of TRF1."J. Biol. Chem. 284:8557-8566(2009) [PubMed] [Europe PMC] [Abstract]
  18. "GNL3L stabilizes the TRF1 complex and promotes mitotic transition."J. Cell Biol. 185:827-839(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Inherited mutations in the helicase RTEL1 cause telomere dysfunction and Hoyeraal-Hreidarsson syndrome."Proc. Natl. Acad. Sci. U.S.A. 110:E3408-E3416(2013) [PubMed] [Europe PMC] [Abstract]
  21. "Solution structure of the DNA-binding domain of human telomeric protein, hTRF1."Structure 6:1057-1065(1998) [PubMed] [Europe PMC] [Abstract]
  22. "Solution structure of a telomeric DNA complex of human TRF1."Structure 9:1237-1251(2001) [PubMed] [Europe PMC] [Abstract]
  23. "Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2."Mol. Cell 8:351-361(2001) [PubMed] [Europe PMC] [Abstract]
  24. "How the human telomeric proteins TRF1 and TRF2 recognize telomeric DNA: a view from high-resolution crystal structures."EMBO Rep. 6:39-45(2005) [PubMed] [Europe PMC] [Abstract]
  25. "A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins."Science 319:1092-1096(2008) [PubMed] [Europe PMC] [Abstract]
  26. "Structural basis of selective ubiquitination of TRF1 by SCFFbx4."Dev. Cell 18:214-225(2010) [PubMed] [Europe PMC] [Abstract]