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Tec Protein Tyrosine Kinase (TEC)

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PSCTK4

Tec Protein Tyrosine Kinase (TEC)
CCC C786
HGNC 11719
MGI 98662
PubMed 8621063
RGD 620973
UniProt P42680
Wiki TEC_(gene
Tyrosine-protein kinase Tec is an enzyme belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain.
Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC786Hu01 Recombinant Tec Protein Tyrosine Kinase (TEC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC786Hu01 Polyclonal Antibody to Tec Protein Tyrosine Kinase (TEC) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Tec Protein Tyrosine Kinase (TEC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tec Protein Tyrosine Kinase (TEC) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC786Mu01 Recombinant Tec Protein Tyrosine Kinase (TEC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC786Mu01 Polyclonal Antibody to Tec Protein Tyrosine Kinase (TEC) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Tec Protein Tyrosine Kinase (TEC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tec Protein Tyrosine Kinase (TEC) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tec Protein Tyrosine Kinase (TEC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tec Protein Tyrosine Kinase (TEC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tec Protein Tyrosine Kinase (TEC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tec Protein Tyrosine Kinase (TEC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tec Protein Tyrosine Kinase (TEC) ELISA Kit Customized Service Offer
  1. "Molecular cloning and analysis of the human Tec protein-tyrosine kinase."Leukemia 8:1663-1672(1994) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases."Biochim. Biophys. Acta 1645:123-132(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding."Mol. Cell. Biol. 14:8432-8437(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Integrin-dependent tyrosine phosphorylation and cytoskeletal translocation of Tec in thrombin-activated platelets."Biochem. Biophys. Res. Commun. 238:247-251(1997) [PubMed] [Europe PMC] [Abstract]
  6. "SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase."J. Biol. Chem. 272:27178-27182(1997) [PubMed] [Europe PMC] [Abstract]
  7. "Grb10/GrbIR as an in vivo substrate of Tec tyrosine kinase."Genes Cells 3:431-441(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Tec is involved in G protein-coupled receptor- and integrin-mediated signalings in human blood platelets."Oncogene 16:2773-2779(1998) [PubMed] [Europe PMC] [Abstract]
  9. "Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase."Proc. Natl. Acad. Sci. U.S.A. 96:11976-11981(1999) [PubMed] [Europe PMC] [Abstract]
  10. "SHIP family inositol phosphatases interact with and negatively regulate the Tec tyrosine kinase."J. Biol. Chem. 279:55089-55096(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Tec protein tyrosine kinase inhibits CD25 expression in human T-lymphocyte."Immunol. Lett. 127:135-142(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Tec-kinase-mediated phosphorylation of fibroblast growth factor 2 is essential for unconventional secretion."Traffic 11:813-826(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]