≡

Transgelin (TAGLN)

[Edit]

SMCC; SM22; TAGLN1; WS3-10; Transgelin Variant 2; 22 kDa actin-binding protein; Protein WS3-10; Smooth muscle protein 22-alpha

Transgelin (TAGLN)
CCC C781
HGNC 11553
MGI 106012
PubMed 8501116
RGD 3723
UniProt Q01995
Wiki TAGLN
Transgelin is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. In contrast to fast and slow skeletal muscle cells that fuse and terminally differentiate, smooth muscle cells are able to simultaneously proliferate and express lineage-restricted proteins. One of these proteins, expressed exclusively in smooth muscles, has been referred to as SM22-alpha, a 22-kD protein with structural similarity to the vertebrate thin filament myofibrillar regulatory protein calponin and the Drosophila muscle protein mp20, neither of which play a direct role in the contractile apparatus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC781Hu01 Recombinant Transgelin (TAGLN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC781Hu01 Polyclonal Antibody to Transgelin (TAGLN) WB; IHC; ICC; IP.
MAC781Hu22 Monoclonal Antibody to Transgelin (TAGLN) WB; IHC; ICC; IP.
Assay Kits SEC781Hu ELISA Kit for Transgelin (TAGLN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transgelin (TAGLN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transgelin (TAGLN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transgelin (TAGLN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transgelin (TAGLN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transgelin (TAGLN) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC781Ra01 Recombinant Transgelin (TAGLN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC781Ra01 Polyclonal Antibody to Transgelin (TAGLN) WB; IHC; ICC; IP.
MAC781Ra21 Monoclonal Antibody to Transgelin (TAGLN) WB; IHC; ICC; IP.
Assay Kits SEC781Ra ELISA Kit for Transgelin (TAGLN) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "A novel gene encoding a smooth muscle protein is overexpressed in senescent human fibroblasts."Biochem. Biophys. Res. Commun. 187:1-7(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Gene cloning and nucleotide sequence of SM22 alpha from the chicken gizzard smooth muscle."Biochem. Int. 23:663-668(1991) [PubMed] [Europe PMC] [Abstract]
  3. "Expression and cytogenetic localization of the human SM22 gene (TAGLN)."Genomics 49:452-457(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Structure and expression of the human SM22alpha gene, assignment of the gene to chromosome 11, and repression of the promoter activity by cytosine DNA methylation."J. Biochem. 122:157-167(1997) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  8. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]