Tachykinin, Precursor 1 (TAC1)

Protachykinin-1 is a protein encoded by the TAC1 gene.Tachykinins are a family of peptides that have similar biologic activities and share a common C-terminal sequence, phe-X-gly-leu-met-NH2, but have distinct N-terminal sequences that convey receptor specificities. Members of this family include substance P, neurokinin A , and neurokinin B (TAC3). The TAC1 gene encodes both substance P and neurokinin A.Krause et al. (1987) showed that 3 forms of preprotachykinin mRNAs, designated alpha, beta, and gamma, arise by alternative splicing events in rat. The beta and gamma forms encode both substance P and neurokinin A, while the alpha form contains only the substance P sequence.Using probes derived from the cloned human gene and a panel of rodent-human somatic cell hybrids.