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Peptidylglycine Alpha Amidating Monooxygenase (PAM)

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PAL; PHM; Peptidylamidoglycolate lyase; Peptidyl-Alpha-hydroxyglycine Alpha-amidating Lyase; Peptidylglycine Alpha-Hydroxylating Monooxygenase

Peptidylglycine Alpha Amidating Monooxygenase (PAM)
CCC C744
HGNC 8596
MGI 97475
PubMed 11251076
RGD 3252
UniProt P19021
Wiki PAM
Peptidyl-glycine alpha-amidating monooxygenase is a multifunctional protein. It has two enzymatically active domains with catalytic activities - peptidylglycine alpha-hydroxylating monooxygenase (PHM) and peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL).
These catalytic domains work sequentially to catalyze neuroendocrine peptides to active alpha-amidated products. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene but some of their full length sequences are not yet known.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC744Hu01 Recombinant Peptidylglycine Alpha Amidating Monooxygenase (PAM) Positive Control; Immunogen; SDS-PAGE; WB.
APC744Hu01 Active Peptidylglycine Alpha Amidating Monooxygenase (PAM) Cell culture; Activity Assays.
EPC744Hu61 Eukaryotic Peptidylglycine Alpha Amidating Monooxygenase (PAM) Positive Control; Immunogen; SDS-PAGE; WB.
APC744Hu61 Active Peptidylglycine Alpha Amidating Monooxygenase (PAM) Cell culture; Activity Assays.
Antibodies PAC744Hu01 Polyclonal Antibody to Peptidylglycine Alpha Amidating Monooxygenase (PAM) WB; IHC; ICC; IP.
MAC744Hu22 Monoclonal Antibody to Peptidylglycine Alpha Amidating Monooxygenase (PAM) WB; IHC; ICC; IP.
Assay Kits SEC744Hu ELISA Kit for Peptidylglycine Alpha Amidating Monooxygenase (PAM) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Peptidylglycine Alpha Amidating Monooxygenase (PAM) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Peptidylglycine Alpha Amidating Monooxygenase (PAM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Peptidylglycine Alpha Amidating Monooxygenase (PAM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Peptidylglycine Alpha Amidating Monooxygenase (PAM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Peptidylglycine Alpha Amidating Monooxygenase (PAM) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins APC744Ra61 Active Peptidylglycine Alpha Amidating Monooxygenase (PAM) Cell culture; Activity Assays.
EPC744Ra61 Eukaryotic Peptidylglycine Alpha Amidating Monooxygenase (PAM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Peptidylglycine Alpha Amidating Monooxygenase (PAM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Peptidylglycine Alpha Amidating Monooxygenase (PAM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Peptidylglycine Alpha Amidating Monooxygenase (PAM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Peptidylglycine Alpha Amidating Monooxygenase (PAM) ELISA Kit Customized Service Offer
  1. "Human peptidylglycine alpha-amidating monooxygenase: cDNA, cloning and functional expression of a truncated form in COS cells."Biochem. Biophys. Res. Commun. 169:551-558(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation and functional expression of human pancreatic peptidylglycine alpha-amidating monooxygenase."Biochem. Biophys. Res. Commun. 205:282-290(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Expression and characterization of human bifunctional peptidylglycine alpha-amidating monooxygenase."Protein Expr. Purif. 28:293-302(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Large-scale concatenation cDNA sequencing."Genome Res. 7:353-358(1997) [PubMed] [Europe PMC] [Abstract]
  8. "Alternative splicing governs sulfation of tyrosine or oligosaccharide on peptidylglycine alpha-amidating monooxygenase."J. Biol. Chem. 269:10946-10955(1994) [PubMed] [Europe PMC] [Abstract]
  9. "The novel kinase peptidylglycine alpha-amidating monooxygenase cytosolic interactor protein 2 interacts with the cytosolic routing determinants of the peptide processing enzyme peptidylglycine alpha-amidating monooxygenase."J. Biol. Chem. 274:34646-34656(1999) [PubMed] [Europe PMC] [Abstract]
  10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]