Peptidylglycine Alpha Amidating Monooxygenase (PAM)
[Edit]PAL; PHM; Peptidylamidoglycolate lyase; Peptidyl-Alpha-hydroxyglycine Alpha-amidating Lyase; Peptidylglycine Alpha-Hydroxylating Monooxygenase
![Peptidylglycine Alpha Amidating Monooxygenase (PAM)](/upload/item/img/Peptidylglycine-Alpha-Amidating-Monooxygenase-(PAM)-92744.jpg)
Peptidyl-glycine alpha-amidating monooxygenase is a multifunctional protein. It has two enzymatically active domains with catalytic activities - peptidylglycine alpha-hydroxylating monooxygenase (PHM) and peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL).
These catalytic domains work sequentially to catalyze neuroendocrine peptides to active alpha-amidated products. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene but some of their full length sequences are not yet known.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPC744Hu01 | Recombinant Peptidylglycine Alpha Amidating Monooxygenase (PAM) | Positive Control; Immunogen; SDS-PAGE; WB. |
APC744Hu01 | Active Peptidylglycine Alpha Amidating Monooxygenase (PAM) | Cell culture; Activity Assays. | |
EPC744Hu61 | Eukaryotic Peptidylglycine Alpha Amidating Monooxygenase (PAM) | Positive Control; Immunogen; SDS-PAGE; WB. | |
APC744Hu61 | Active Peptidylglycine Alpha Amidating Monooxygenase (PAM) | Cell culture; Activity Assays. | |
Antibodies | PAC744Hu01 | Polyclonal Antibody to Peptidylglycine Alpha Amidating Monooxygenase (PAM) | WB; IHC; ICC; IP. |
MAC744Hu22 | Monoclonal Antibody to Peptidylglycine Alpha Amidating Monooxygenase (PAM) | WB; IHC; ICC; IP. | |
Assay Kits | SEC744Hu | ELISA Kit for Peptidylglycine Alpha Amidating Monooxygenase (PAM) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Peptidylglycine Alpha Amidating Monooxygenase (PAM) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Peptidylglycine Alpha Amidating Monooxygenase (PAM) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Peptidylglycine Alpha Amidating Monooxygenase (PAM) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Peptidylglycine Alpha Amidating Monooxygenase (PAM) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Peptidylglycine Alpha Amidating Monooxygenase (PAM) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | APC744Ra61 | Active Peptidylglycine Alpha Amidating Monooxygenase (PAM) | Cell culture; Activity Assays. |
EPC744Ra61 | Eukaryotic Peptidylglycine Alpha Amidating Monooxygenase (PAM) | Positive Control; Immunogen; SDS-PAGE; WB. | |
Antibodies | n/a | Monoclonal Antibody to Peptidylglycine Alpha Amidating Monooxygenase (PAM) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Peptidylglycine Alpha Amidating Monooxygenase (PAM) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Peptidylglycine Alpha Amidating Monooxygenase (PAM) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Peptidylglycine Alpha Amidating Monooxygenase (PAM) | ELISA Kit Customized Service Offer |
- "Human peptidylglycine alpha-amidating monooxygenase: cDNA, cloning and functional expression of a truncated form in COS cells."Biochem. Biophys. Res. Commun. 169:551-558(1990) [PubMed] [Europe PMC] [Abstract]
- "Isolation and functional expression of human pancreatic peptidylglycine alpha-amidating monooxygenase."Biochem. Biophys. Res. Commun. 205:282-290(1994) [PubMed] [Europe PMC] [Abstract]
- "Expression and characterization of human bifunctional peptidylglycine alpha-amidating monooxygenase."Protein Expr. Purif. 28:293-302(2003) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Large-scale concatenation cDNA sequencing."Genome Res. 7:353-358(1997) [PubMed] [Europe PMC] [Abstract]
- "Alternative splicing governs sulfation of tyrosine or oligosaccharide on peptidylglycine alpha-amidating monooxygenase."J. Biol. Chem. 269:10946-10955(1994) [PubMed] [Europe PMC] [Abstract]
- "The novel kinase peptidylglycine alpha-amidating monooxygenase cytosolic interactor protein 2 interacts with the cytosolic routing determinants of the peptide processing enzyme peptidylglycine alpha-amidating monooxygenase."J. Biol. Chem. 274:34646-34656(1999) [PubMed] [Europe PMC] [Abstract]
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
- "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
- "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]