Phosphatidic Acid Phosphatase Type 2A (PPAP2A)
[Edit]PPAP2-A; LLP1a; LPP1; PAP-2a; PAP2; PAP2a2; PAP2alpha2; PAPalpha1; Lipid phosphate phosphohydrolase 1; Phosphatidate phosphohydrolase type 2a
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Lipid phosphate phosphohydrolase 1 is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D.
This protein is an integral membrane glycoprotein, and has been shown to be a surface enzyme that plays an active role in the hydrolysis and uptake of lipids from extracellular space. The expression of this gene is found to be regulated by androgen in a prostatic adenocarcinoma cell line. At least two alternatively spliced transcript variants encoding distinct isoforms have been described.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Phosphatidic Acid Phosphatase Type 2A (PPAP2A) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Phosphatidic Acid Phosphatase Type 2A (PPAP2A) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Phosphatidic Acid Phosphatase Type 2A (PPAP2A) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Phosphatidic Acid Phosphatase Type 2A (PPAP2A) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Phosphatidic Acid Phosphatase Type 2A (PPAP2A) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Phosphatidic Acid Phosphatase Type 2A (PPAP2A) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Phosphatidic Acid Phosphatase Type 2A (PPAP2A) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Phosphatidic Acid Phosphatase Type 2A (PPAP2A) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Phosphatidic Acid Phosphatase Type 2A (PPAP2A) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Phosphatidic Acid Phosphatase Type 2A (PPAP2A) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Phosphatidic Acid Phosphatase Type 2A (PPAP2A) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Phosphatidic Acid Phosphatase Type 2A (PPAP2A) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Phosphatidic Acid Phosphatase Type 2A (PPAP2A) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Phosphatidic Acid Phosphatase Type 2A (PPAP2A) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Phosphatidic Acid Phosphatase Type 2A (PPAP2A) | ELISA Kit Customized Service Offer |
- "Cloning and characterization of two human isozymes of Mg2+-independent phosphatidic acid phosphatase."J. Biol. Chem. 272:24572-24578(1997) [PubMed] [Europe PMC] [Abstract]
- "Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells."DNA Cell Biol. 17:377-385(1998) [PubMed] [Europe PMC] [Abstract]
- "Identification of the phosphatidic acid phosphatase type 2a isozyme as an androgen-regulated gene in the human prostatic Adenocarcinoma cell line LNCaP."J. Biol. Chem. 273:4660-4665(1998) [PubMed] [Europe PMC] [Abstract]
- "Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform."J. Biol. Chem. 273:22059-22067(1998) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Lipid phosphate phosphatases regulate lysophosphatidic acid production and signaling in platelets: studies using chemical inhibitors of lipid phosphate phosphatase activity."J. Biol. Chem. 278:43214-43223(2003) [PubMed] [Europe PMC] [Abstract]