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Nicastrin (NCSTN)

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APH2; NCT

Nicastrin (NCSTN)
CCC C680
HGNC 17091
MGI 1891700
PubMed 16096062
RGD 631418
UniProt Q92542
Wiki Nicastrin
Nicastrin (abbreviated NCT) is a protein that is part of the gamma secretase protein complex, which is one of the proteases involved in processing amyloid precursor protein (APP) to the short Alzheimer's disease-associated peptide amyloid beta. The other proteins in the complex are presenilin, which is the catalytically active component of the complex, APH-1 (anterior pharynx-defective 1), and PEN-2 (presenilin enhancer 2). Nicastrin itself is not catalytically active, but instead promotes the maturation and proper trafficking of the other proteins in the complex, all of which undergo significant post-translational modification before becoming active in the cell. Nicastrin has also been identified as a regulator of neprilysin, an enzyme involved in the degradation of amyloid beta fragment.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC680Hu01 Recombinant Nicastrin (NCSTN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC680Hu01 Polyclonal Antibody to Nicastrin (NCSTN) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Nicastrin (NCSTN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nicastrin (NCSTN) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nicastrin (NCSTN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nicastrin (NCSTN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nicastrin (NCSTN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nicastrin (NCSTN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nicastrin (NCSTN) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC680Ra01 Recombinant Nicastrin (NCSTN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC680Ra01 Polyclonal Antibody to Nicastrin (NCSTN) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Nicastrin (NCSTN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nicastrin (NCSTN) ELISA Kit Customized Service Offer
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  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
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  6. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
  7. "Nicastrin, a key regulator of presenilin function, is expressed constitutively in human neural cell lines."Neuropathology 21:115-122(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Proteomic analysis of early melanosomes: identification of novel melanosomal proteins."J. Proteome Res. 2:69-79(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2."Proc. Natl. Acad. Sci. U.S.A. 100:6382-6387(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Reconstitution of gamma-secretase activity."Nat. Cell Biol. 5:486-488(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Gamma-secretase gene mutations in familial acne inversa."Science 330:1065-1065(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Confirmation by exome sequencing of the pathogenic role of NCSTN mutations in acne inversa (hidradenitis suppurativa)." J. Invest. Dermatol. 131:1570-1572(2011) [PubMed] [Europe PMC] [Abstract]
  18. "Two novel mutations of the nicastrin gene in Chinese patients with acne inversa."Br. J. Dermatol. 165:415-418(2011) [PubMed] [Europe PMC] [Abstract]