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Neurochondrin (NCDN)

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Norbin

Neurochondrin (NCDN)
CCC C654
HGNC 17597
MGI 1347351
PubMed 15790563
RGD 621734
UniProt Q9UBB6
Wiki Neurochondrin
Neurochondrin is a leucine-rich cytoplasmic protein, which is highly similar to a mouse protein that negatively regulates Ca/calmodulin-dependent protein kinase II phosphorylation and may be essential for spatial learning processes. Several alternatively spliced transcript variants of this gene have been described.Abundantly expressed in whole adult brain and in all individual brain regions examined, including spinal cord. Weakly expressed in ovary, testis, and fetal brain.
According to one study, Norbin can modulate signaling activty and expression of metabotropic glutamate receptor 5; modulating mice with targeted deletion of NCDN in the brain have phenotypic traits usually found in the rodent models of schizophrenia, including disruptions in prepulse inhibition.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neurochondrin (NCDN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neurochondrin (NCDN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neurochondrin (NCDN) Polyclonal Antibody Customized Service Offer
Assay Kits SEC654Hu ELISA Kit for Neurochondrin (NCDN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neurochondrin (NCDN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neurochondrin (NCDN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neurochondrin (NCDN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neurochondrin (NCDN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neurochondrin (NCDN) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC654Ra01 Recombinant Neurochondrin (NCDN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC654Ra01 Polyclonal Antibody to Neurochondrin (NCDN) WB,IHC
MAC654Ra21 Monoclonal Antibody to Neurochondrin (NCDN) WB; IHC; ICC; IP.
Assay Kits SEC654Ra ELISA Kit for Neurochondrin (NCDN) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Molecular cloning and expression of human neurochondrin-1 and -2."Biochim. Biophys. Acta 1446:397-402(1999) [PubMed] [Europe PMC] [Abstract]
  2. ErratumBiochim. Biophys. Acta 1490:367-368(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Interaction of neurochondrin with the melanin-concentrating hormone receptor 1 interferes with G protein-coupled signal transduction but not agonist-mediated internalization."J. Biol. Chem. 281:32496-32507(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  10. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]