Myelin Transcription Factor 1 (MYT1)

[Edit]

MTF1; MYTI; PLPB1; Proteolipid protein-binding protein

Myelin Transcription Factor 1 (MYT1)
Myelin transcription factor 1 is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system. Binds to the promoter regions of proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendrogalia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription.Expressed in neural progenitors and oligodendrocyte lineage cells. More highly expressed in oligodendrocyte progenitors than in differentiated oligodendrocytes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC637Hu01 Recombinant Myelin Transcription Factor 1 (MYT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC637Hu01 Polyclonal Antibody to Myelin Transcription Factor 1 (MYT1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Myelin Transcription Factor 1 (MYT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myelin Transcription Factor 1 (MYT1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC637Mu01 Recombinant Myelin Transcription Factor 1 (MYT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC637Mu01 Polyclonal Antibody to Myelin Transcription Factor 1 (MYT1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Myelin Transcription Factor 1 (MYT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myelin Transcription Factor 1 (MYT1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myelin Transcription Factor 1 (MYT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myelin Transcription Factor 1 (MYT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myelin Transcription Factor 1 (MYT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myelin Transcription Factor 1 (MYT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myelin Transcription Factor 1 (MYT1) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Novel member of the zinc finger superfamily: a C2-HC finger that recognizes a glia-specific gene."Mol. Cell. Biol. 12:5632-5639(1992) [PubMed] [Europe PMC] [Abstract]
  6. "Expression of myelin transcription factor I (MyTI), a 'zinc-finger' DNA-binding protein, in developing oligodendrocytes."Glia 14:303-321(1995) [PubMed] [Europe PMC] [Abstract]
  7. "The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase."Proc. Natl. Acad. Sci. U.S.A. 100:2284-2289(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Myelin transcription factor 1 (Myt1) modulates the proliferation and differentiation of oligodendrocyte lineage cells."Mol. Cell. Neurosci. 25:111-123(2004) [PubMed] [Europe PMC] [Abstract]