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TNF Like Ligand 1A (TL1A)

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TNFSF15; TL1; VEGI; VEGI192A; Tumor Necrosis Factor(ligand)Superfamily,Member 15; TNF Superfamily Ligand TL1A; TNF Ligand-Related Molecule 1; Vascular Endothelial Growth Inhibitor

TNF Like Ligand 1A (TL1A)
CCC C602
HGNC 11931
MGI 2180140
PubMed 24023314
RGD 628735
UniProt O95150
Wiki TNFSF15

VEGI is an anti-angiogenic protein. It belongs to tumor necrosis factor (ligand) superfamily, where it is member 15. The protein is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. An additional isoform encoded by an alternatively spliced transcript variant has been reported but the sequence of this transcript has not been determined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC602Hu01 Recombinant TNF Like Ligand 1A (TL1A) Positive Control; Immunogen; SDS-PAGE; WB.
APC602Hu01 Active TNF Like Ligand 1A (TL1A) Cell culture; Activity Assays.
Antibodies PAC602Hu01 Polyclonal Antibody to TNF Like Ligand 1A (TL1A) WB,IHC
MAC602Hu21 Monoclonal Antibody to TNF Like Ligand 1A (TL1A) WB; IHC; ICC; IP.
Assay Kits SEC602Hu ELISA Kit for TNF Like Ligand 1A (TL1A) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TNF Like Ligand 1A (TL1A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TNF Like Ligand 1A (TL1A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TNF Like Ligand 1A (TL1A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TNF Like Ligand 1A (TL1A) CLIA Kit Customized Service Offer
n/a ELISA Kit for TNF Like Ligand 1A (TL1A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC602Ra01 Recombinant TNF Like Ligand 1A (TL1A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC602Ra01 Polyclonal Antibody to TNF Like Ligand 1A (TL1A) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for TNF Like Ligand 1A (TL1A) CLIA Kit Customized Service Offer
n/a ELISA Kit for TNF Like Ligand 1A (TL1A) ELISA Kit Customized Service Offer
  1. "VEGI, a novel cytokine of the tumor necrosis factor family, is an angiogenesis inhibitor that suppresses the growth of colon carcinomas in vivo."FASEB J. 13:181-189(1999) [PubMed] [Europe PMC] [Abstract]
  2. "A novel secreted splice variant of vascular endothelial cell growth inhibitor."FASEB J. 16:742-744(2002) [PubMed] [Europe PMC] [Abstract]
  3. "TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator." Immunity 16:479-492(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Characterization of a novel TNF-like ligand and recently described TNF ligand and TNF receptor superfamily genes and their constitutive and inducible expression in hematopoietic and non-hematopoietic cells."Gene 204:35-46(1997) [PubMed] [Europe PMC] [Abstract]
  8. "VEGI, a new member of the TNF family activates nuclear factor-kappa B and c-Jun N-terminal kinase and modulates cell growth."Oncogene 18:6496-6504(1999) [PubMed] [Europe PMC] [Abstract]
  9. "X-ray crystal structure of TNF ligand family member TL1A at 2.1A."Biochem. Biophys. Res. Commun. 364:1-6(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Decoy strategies: the structure of TL1A:DcR3 complex."Structure 19:162-171(2011) [PubMed] [Europe PMC] [Abstract]