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Vesicle Docking Protein (VDP)

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TAP; P115; USO1; General Vesicular Transport Factor p115; Transcytosis Associated Protein

Vesicle Docking Protein (VDP)
CCC C590
HGNC 30904
MGI 1929095
PubMed 9478999
RGD 621604
UniProt O60763
Wiki USO1
General vesicular transport factor p115 is a peripheral membrane protein which recycles between the cytosol and the Golgi apparatus during interphase.
It is regulated by phosphorylation: dephosphorylated protein associates with the Golgi membrane and dissociates from the membrane upon phosphorylation. Ras-associated protein 1 recruits this protein to coat protein complex II (COPII) vesicles during budding from the endoplasmic reticulum, where it interacts with a set of COPII vesicle-associated SNAREs to form a cis-SNARE complex that promotes targeting to the Golgi apparatus. Transport from the ER to the cis/medial Golgi compartments requires the action of this gene product, GM130 and giantin in a sequential manner.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC590Hu01 Recombinant Vesicle Docking Protein (VDP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Vesicle Docking Protein (VDP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vesicle Docking Protein (VDP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Vesicle Docking Protein (VDP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vesicle Docking Protein (VDP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC590Mu01 Recombinant Vesicle Docking Protein (VDP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Vesicle Docking Protein (VDP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vesicle Docking Protein (VDP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Vesicle Docking Protein (VDP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vesicle Docking Protein (VDP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Vesicle Docking Protein (VDP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Vesicle Docking Protein (VDP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vesicle Docking Protein (VDP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Vesicle Docking Protein (VDP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vesicle Docking Protein (VDP) ELISA Kit Customized Service Offer
  1. "Phosphorylation of the vesicle docking protein p115 regulates its association with the Golgi membrane."J. Biol. Chem. 273:5385-5388(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
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  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "The Golgi-associated protein p115 mediates the secretion of macrophage migration inhibitory factor."J. Immunol. 182:6896-6906(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Unusual armadillo fold in the human general vesicular transport factor p115."PLoS ONE 4:E4656-E4656(2009) [PubMed] [Europe PMC] [Abstract]