Urocortin 2 (UCN2)
[Edit]URP; SRP; UCN-II; UCNII; Stresscopin-Related Peptide; Urocortin-related peptide
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Urocortin-2 is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II.
Urocortin (UCN) II is a 38 amino acid member of the mammalian corticotropin-releasing hormone (CRH) peptide family, which also includes CRH, UCN I, and UCN III . CRH mainly binds to type 1 CRH receptors (CRH1), while UCN II and III bind primarily to type 2 CRH receptors, and UCN I binds to both (CRH2) .
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC585Mu01 | Recombinant Urocortin 2 (UCN2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPC585Mu02 | Recombinant Urocortin 2 (UCN2) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAC585Mu01 | Polyclonal Antibody to Urocortin 2 (UCN2) | WB; IHC; ICC; IP. |
| PAC585Mu02 | Polyclonal Antibody to Urocortin 2 (UCN2) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC585Mu | ELISA Kit for Urocortin 2 (UCN2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| CEC585Mu | ELISA Kit for Urocortin 2 (UCN2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC585Ra01 | Recombinant Urocortin 2 (UCN2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| CPC585Ra21 | OVA Conjugated Urocortin 2 (UCN2) | Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAC585Ra01 | Polyclonal Antibody to Urocortin 2 (UCN2) | WB; IHC; ICC; IP. |
| MAC585Ra21 | Monoclonal Antibody to Urocortin 2 (UCN2) | WB; IHC; ICC; IP. | |
| PAC585Ra08 | Polyclonal Antibody to Urocortin 2 (UCN2) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC585Ra | ELISA Kit for Urocortin 2 (UCN2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor."Nat. Med. 7:605-611(2001) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Posttranslational processing of human and mouse urocortin 2: characterization and bioactivity of gene products."Endocrinology 154:1553-1564(2013) [PubMed] [Europe PMC] [Abstract]
- "Common and divergent structural features of a series of corticotropin releasing factor-related peptides."J. Am. Chem. Soc. 129:16102-16114(2007) [PubMed] [Europe PMC] [Abstract]
- "Structural basis for hormone recognition by the Human CRFR2{alpha} G protein-coupled receptor."J. Biol. Chem. 285:40351-40361(2010) [PubMed] [Europe PMC] [Abstract]