≡

Microtubule Actin Crosslinking Factor 1 (MACF1)

[Edit]

ACF7; MACF; OFC4; Actin Cross-Linking Factor; Actin cross-linking family protein 7; 620 kDa Actin Binding Protein; Macrophin 1; Trabeculin-Alpha

Microtubule Actin Crosslinking Factor 1 (MACF1)
CCC C581
HGNC 13664
MGI 108559
PubMed 16815997
UniProt Q96PK2
Wiki MACF1
Microtubule-actin cross-linking factor 1 is a protein belongs to the plakin family of cytoskeletal linker proteins. This protein family forms bridges between different cytoskeletal elements through specialized modular domains. The encoded protein is one of the largest size proteins identified in human cytoskeletal proteins.
It has functional actin and microtubule binding domains, and it appears to stabilize actin at sites where microtubules and microfilaments meet. It may function in microtubule dynamics to facilitate actin-microtubule interactions at the cell periphery and to couple the microtubule network to cellular junctions. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Microtubule Actin Crosslinking Factor 1 (MACF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Microtubule Actin Crosslinking Factor 1 (MACF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Microtubule Actin Crosslinking Factor 1 (MACF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Microtubule Actin Crosslinking Factor 1 (MACF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Microtubule Actin Crosslinking Factor 1 (MACF1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Microtubule Actin Crosslinking Factor 1 (MACF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Microtubule Actin Crosslinking Factor 1 (MACF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Microtubule Actin Crosslinking Factor 1 (MACF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Microtubule Actin Crosslinking Factor 1 (MACF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Microtubule Actin Crosslinking Factor 1 (MACF1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Microtubule Actin Crosslinking Factor 1 (MACF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Microtubule Actin Crosslinking Factor 1 (MACF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Microtubule Actin Crosslinking Factor 1 (MACF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Microtubule Actin Crosslinking Factor 1 (MACF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Microtubule Actin Crosslinking Factor 1 (MACF1) ELISA Kit Customized Service Offer
  1. "Molecular cloning of macrophin, a human homologue of Drosophila kakapo with a close structural similarity to plectin and dystrophin."Biochem. Biophys. Res. Commun. 264:568-574(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and characterization of human trabeculin-alpha, a giant protein defining a new family of actin-binding proteins."J. Biol. Chem. 274:33522-33530(1999) [PubMed] [Europe PMC] [Abstract]
  3. "MACF1 gene structure: a hybrid of plectin and dystrophin."Mamm. Genome 12:852-861(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain."DNA Res. 4:345-349(1997) [PubMed] [Europe PMC] [Abstract]
  7. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Interaction between p230 and MACF1 is associated with transport of a glycosyl phosphatidyl inositol-anchored protein from the Golgi to the cell periphery."Exp. Cell Res. 298:388-398(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Microtubule actin crosslinking factor 1b: a novel plakin that localizes to the Golgi complex."J. Cell Sci. 118:3727-3738(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  15. "ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells."Proc. Natl. Acad. Sci. U.S.A. 107:18517-18522(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  19. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  20. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]