Lysophospholipase I (LYPLA1)

Lysophospholipids (LysoPLs) are detergent-like intermediates in phospholipid metabolism. Increased LysoPL levels have been detected in a variety of diseases including atherosclerosis and hyperlipidemia. In some cases, increased levels of LysoPLs are hypothesized to result from a dysfunction of LysoPL-regulating enzymes including lysophospholipases, which act on biologic membranes to regulate the level of LysoPLs by hydrolysis.

Acyl-protein thioesterase 1 hydrolyzes lysophosphatidylcholine in both monomeric and micellar forms. The use of alternate polyadenylation sites has been found for this gene. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet.