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Lectin, Mannose Binding 1 (LMAN1)

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F5F8D; FMFD1; MCFD1; MR60; Gp58; Protein ERGIC-53; Coagulation Factor V-Factor VIII Combined Deficiency; Endoplasmic Reticulum-Golgi Intermediate Compartment Protein 53

Lectin, Mannose Binding 1 (LMAN1)
CCC C567
HGNC 6631
MGI 1917611
PubMed 14629470
RGD 71020
UniProt P49257
Wiki LMAN1
Protein ERGIC-53 isa type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments.
The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC567Hu01 Recombinant Lectin, Mannose Binding 1 (LMAN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC567Hu01 Polyclonal Antibody to Lectin, Mannose Binding 1 (LMAN1) WB,IHC,ICC/IF; FCM
Assay Kits n/a CLIA Kit for Lectin, Mannose Binding 1 (LMAN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lectin, Mannose Binding 1 (LMAN1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lectin, Mannose Binding 1 (LMAN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lectin, Mannose Binding 1 (LMAN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lectin, Mannose Binding 1 (LMAN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lectin, Mannose Binding 1 (LMAN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lectin, Mannose Binding 1 (LMAN1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lectin, Mannose Binding 1 (LMAN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lectin, Mannose Binding 1 (LMAN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lectin, Mannose Binding 1 (LMAN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lectin, Mannose Binding 1 (LMAN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lectin, Mannose Binding 1 (LMAN1) ELISA Kit Customized Service Offer
  1. "ERGIC-53, a membrane protein of the ER-Golgi intermediate compartment, carries an ER retention motif."Eur. J. Cell Biol. 61:1-9(1993) [PubMed] [Europe PMC] [Abstract]
  2. "ERGIC-53, a membrane protein of the endoplasmic reticulum-Golgi intermediate compartment, is identical to MR60, an intracellular mannose-specific lectin of myelomonocytic cells."J. Biol. Chem. 270:3551-3553(1995) [PubMed] [Europe PMC] [Abstract]
  3. "ERGIC-53 gene structure and mutation analysis in 19 combined factors V and VIII deficiency families." Blood 93:2261-2266(1999) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  6. "A putative novel class of animal lectins in the secretory pathway homologous to leguminous lectins."Cell 77:625-626(1994) [PubMed] [Europe PMC] [Abstract]
  7. "Cluster analysis of an extensive human breast cancer cell line protein expression map database."Proteomics 2:212-223(2002) [PubMed] [Europe PMC] [Abstract]
  8. "ER export of ERGIC-53 is controlled by cooperation of targeting determinants in all three of its domains."J. Cell Sci. 116:4429-4440(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex."Nat. Genet. 34:220-225(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Oligomerization and intracellular localization of the glycoprotein receptor ERGIC-53 is independent of disulfide bonds."J. Mol. Biol. 354:556-568(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "TMEM115 is an integral membrane protein of the Golgi complex involved in retrograde transport."J. Cell Sci. 127:2825-2839(2014) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Crystal structure of the LMAN1-CRD/MCFD2 transport receptor complex provides insight into combined deficiency of factor V and factor VIII."FEBS Lett. 584:878-882(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Structural basis for the cooperative interplay between the two causative gene products of combined factor V and factor VIII deficiency."Proc. Natl. Acad. Sci. U.S.A. 107:4034-4039(2010) [PubMed] [Europe PMC] [Abstract]
  16. "A novel missense mutation causing abnormal LMAN1 in a Japanese patient with combined deficiency of factor V and factor VIII."Am. J. Hematol. 84:738-742(2009) [PubMed] [Europe PMC] [Abstract]