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Inner Centromere Protein (INCENP)

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Inner Centromere Protein Antigens

Inner Centromere Protein (INCENP)
CCC C543
HGNC 6058
MGI 1313288
PubMed 11352945
RGD 1305292
UniProt Q9NQS7
Wiki INCENP
In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins . The constitutive proteins include CENPA, CENPB, CENPC1, and CENPD. The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle . These include CENPE; MCAK ; KID; cytoplasmic dynein ; CliPs; and CENPF/mitosin . The inner centromere proteins (INCENPs) , the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inner Centromere Protein (INCENP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inner Centromere Protein (INCENP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inner Centromere Protein (INCENP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inner Centromere Protein (INCENP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inner Centromere Protein (INCENP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inner Centromere Protein (INCENP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inner Centromere Protein (INCENP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inner Centromere Protein (INCENP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inner Centromere Protein (INCENP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inner Centromere Protein (INCENP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inner Centromere Protein (INCENP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inner Centromere Protein (INCENP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inner Centromere Protein (INCENP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inner Centromere Protein (INCENP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inner Centromere Protein (INCENP) ELISA Kit Customized Service Offer
  1. "Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells."Chromosoma 110:65-74(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C."J. Biol. Chem. 279:47201-47211(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "INCENP centromere and spindle targeting: identification of essential conserved motifs and involvement of heterochromatin protein HP1."J. Cell Biol. 143:1763-1774(1998) [PubMed] [Europe PMC] [Abstract]
  6. "INCENP binds directly to tubulin and requires dynamic microtubules to target to the cleavage furrow."Exp. Cell Res. 262:122-127(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis."Mol. Biol. Cell 14:3325-3341(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo."J. Biol. Chem. 279:5655-5660(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle."J. Cell Biol. 166:179-191(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  11. "EVI5 protein associates with the INCENP-aurora B kinase-survivin chromosomal passenger complex and is involved in the completion of cytokinesis."Exp. Cell Res. 312:2325-2335(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1."Mol. Biol. Cell 17:3705-3716(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  15. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation."Nat. Cell Biol. 12:719-727(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  21. "PAR, a protein involved in the cell cycle, is functionally related to chromosomal passenger proteins."Int. J. Oncol. 38:777-785(2011) [PubMed] [Europe PMC] [Abstract]
  22. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  23. "Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together."Cell 131:271-285(2007) [PubMed] [Europe PMC] [Abstract]