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General Transcription Factor IIA, Polypeptide 1 (GTF2A1)

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GTF2-A1; TF2A1; TFIIA; Transcription Initiation Factor IIA Subunit 1; Transcription initiation factor TFIIA 42 kDa subunit

General Transcription Factor IIA, Polypeptide 1 (GTF2A1)
CCC C536
HGNC 4646
MGI 1933277
PubMed 19724865
RGD 69246
UniProt P52655
Wiki GTF2A1
Transcription factor TFIIA is a nuclear protein involved in the RNA polymerase II-dependent transcription of DNA. TFIIA is one of several general (basal) transcription factors (GTFs) that are required for all transcription events that use RNA polymerase II. Other GTFs include TFIID, a complex composed of the TATA binding protein TBP and TBP-associated factors (TAFs), as well as the factors TFIIB, TFIIE, TFIIF, and TFIIH.
Together, these factors are responsible for promoter recognition and the formation of a transcription preinitiation complex (PIC) capable of initiating RNA synthesis from a DNA template.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC536Hu01 Recombinant General Transcription Factor IIA, Polypeptide 1 (GTF2A1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC536Hu01 Polyclonal Antibody to General Transcription Factor IIA, Polypeptide 1 (GTF2A1) WB; IHC; ICC; IP.
MAC536Hu22 Monoclonal Antibody to General Transcription Factor IIA, Polypeptide 1 (GTF2A1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for General Transcription Factor IIA, Polypeptide 1 (GTF2A1) CLIA Kit Customized Service Offer
n/a ELISA Kit for General Transcription Factor IIA, Polypeptide 1 (GTF2A1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant General Transcription Factor IIA, Polypeptide 1 (GTF2A1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to General Transcription Factor IIA, Polypeptide 1 (GTF2A1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to General Transcription Factor IIA, Polypeptide 1 (GTF2A1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for General Transcription Factor IIA, Polypeptide 1 (GTF2A1) CLIA Kit Customized Service Offer
n/a ELISA Kit for General Transcription Factor IIA, Polypeptide 1 (GTF2A1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant General Transcription Factor IIA, Polypeptide 1 (GTF2A1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to General Transcription Factor IIA, Polypeptide 1 (GTF2A1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to General Transcription Factor IIA, Polypeptide 1 (GTF2A1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for General Transcription Factor IIA, Polypeptide 1 (GTF2A1) CLIA Kit Customized Service Offer
n/a ELISA Kit for General Transcription Factor IIA, Polypeptide 1 (GTF2A1) ELISA Kit Customized Service Offer
  1. "Isolation of a cDNA encoding the largest subunit of TFIIA reveals functions important for activated transcription."Genes Dev. 7:2246-2257(1993) [PubMed] [Europe PMC] [Abstract]
  2. "A single cDNA, hTFIIA/alpha, encodes both the p35 and p19 subunits of human TFIIA."Genes Dev. 7:2220-2234(1993) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "TAC, a TBP-sans-TAFs complex containing the unprocessed TFIIAalphabeta precursor and the TFIIAgamma subunit."Mol. Cell 6:527-537(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Taf(II) 250 phosphorylates human transcription factor IIA on serine residues important for TBP binding and transcription activity."J. Biol. Chem. 276:15886-15892(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Cleavage and proteasome-mediated degradation of the basal transcription factor TFIIA."EMBO J. 23:3083-3091(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Uncleaved TFIIA is a substrate for taspase 1 and active in transcription."Mol. Cell. Biol. 26:2728-2735(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]