Dual Oxidase Maturation Factor 2 (DUOXA2)

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Dual oxidase activator 2

Dual Oxidase Maturation Factor 2 (DUOXA2)
DUOXA2, a resident endoplasmic reticulum (ER) protein, is required for the maturation and plasma membrane localization of DUOX2. The deduced 320-amino acid protein was predicted to have 5 transmembrane spans, including a reverse signal anchor with an extracellular N terminus (type III) and 3 N-glycosylation sites clustered within an extended external loop between transmembrane helices 2 and 3.
Northern blot analysis detected a transcript of about 1.5 kb highly expressed in thyroid. Expression was much weaker in salivary gland and was not detected in other tissues examined. Epitope-tagged DUOXA2 showed an intracellular distribution similar to the ER marker protein calnexin.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dual Oxidase Maturation Factor 2 (DUOXA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dual Oxidase Maturation Factor 2 (DUOXA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dual Oxidase Maturation Factor 2 (DUOXA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dual Oxidase Maturation Factor 2 (DUOXA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dual Oxidase Maturation Factor 2 (DUOXA2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dual Oxidase Maturation Factor 2 (DUOXA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dual Oxidase Maturation Factor 2 (DUOXA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dual Oxidase Maturation Factor 2 (DUOXA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dual Oxidase Maturation Factor 2 (DUOXA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dual Oxidase Maturation Factor 2 (DUOXA2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dual Oxidase Maturation Factor 2 (DUOXA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dual Oxidase Maturation Factor 2 (DUOXA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dual Oxidase Maturation Factor 2 (DUOXA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dual Oxidase Maturation Factor 2 (DUOXA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dual Oxidase Maturation Factor 2 (DUOXA2) ELISA Kit Customized Service Offer
  1. "Identification of the maturation factor for dual oxidase. Evolution of an eukaryotic operon equivalent."J. Biol. Chem. 281:18269-18272(2006) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Biallelic inactivation of the dual oxidase maturation factor 2 (DUOXA2) gene as a novel cause of congenital hypothyroidism."J. Clin. Endocrinol. Metab. 93:605-610(2008) [PubMed] [Europe PMC] [Abstract]